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Clinical Trials/NCT04459624
NCT04459624
Completed
Not Applicable

Comparison of the Effects of Quadratus Lumborum Block (QLB) and Erector Spina Plane Block (ESP) on Postoperative Pain in Open Nephrectomy

Eskisehir Osmangazi University1 site in 1 country40 target enrollmentJuly 20, 2020

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Pain, Postoperative
Sponsor
Eskisehir Osmangazi University
Enrollment
40
Locations
1
Primary Endpoint
Effect of QLB2 and ESP on postoperative pain scores in nephrectomy surgery
Status
Completed
Last Updated
4 years ago

Overview

Brief Summary

Postoperative pain is important due to the limitation of physical functions, delay in recovery of quality of life, long-term opiate use, length of hospital stay, increased care costs and early postoperative pain trigger chronic pain. It is associated with postoperative morbidity. Multimodal analgesia techniques with fascial plan blocks are frequently used.The investigators aimed to evaluate the effect of QLB2 and ESP on postoperative pain scores in nephrectomy surgery, total opiate consumption, initial analgesia requirement, additional analgesia consumption, patient and surgeon satisfaction.

Detailed Description

At the end of the operation, patients will be randomly divided into 2 groups as Group E (ESP block) and Group Q (QLB). The blocks will be administered under general anesthesia in lateral position by same anesthesiologist. Group E (ESP block) will be applied 20 ml of %0.25 bupivacaine between the erector spina muscle and transverse process at the 8th thoracic level. Group Q (QLB2 block) will be applied 20 ml of %0.25 bupivacaine at lumbar interfacial triangle (LIFT). At the end of the operation, the patients with a Modified aldreate score ≥9 will be sent from the postoperative anesthesia unit. All patients will be equipped with an IV morphine patient-controlled analgesia (PCA) device. The solution will be prepared such that morphine is 0.5 mg / ml. PCA 1mg bolus dose will be delivered with 10 min lock-out time. In the postoperative period, the patient was evaluated by another researcher who blind to the groups at the 1st and 6th, 12th and 24th hours. Visual pain scores (VAS) in rest and movement, hemodynamic values, morphine consumption, initial analgesic requirement, nausea-vomiting score, ramsey sedation scale, length of hospital stay, patient and surgeon satisfaction, and postoperative complications will be recorded.

Registry
clinicaltrials.gov
Start Date
July 20, 2020
End Date
January 31, 2022
Last Updated
4 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
Eskisehir Osmangazi University
Responsible Party
Principal Investigator
Principal Investigator

Meryem Onay

Specialist Doctor-Anesthesiologist

Eskisehir Osmangazi University

Eligibility Criteria

Inclusion Criteria

  • Partial or radical nephrectomy
  • American Society of Anesthesiologist physical status I-III

Exclusion Criteria

  • Infection in the incision area
  • Coagulation disorder
  • Known allergy history against to the study drugs
  • Lack of adequate cognitive activity in the use of patient-controlled analgesia and VAS

Outcomes

Primary Outcomes

Effect of QLB2 and ESP on postoperative pain scores in nephrectomy surgery

Time Frame: 24 hours

Visual analog scale at rest and movement (0 (no pain)-10 (unbearable pain))

Secondary Outcomes

  • Total opiate consumption(24 hours)

Study Sites (1)

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