NCT04532814进行中（未招募）不适用
Exercise-stimulated Muscle Glucose Uptake in Upper Body Obesity
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- Mayo Clinic
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Skeletal muscle glucose uptake
研究概览
简要总结
The purpose of this study is to provide the first integrated examination of the interaction between muscle insulin action and exercise-stimulated muscle glucose uptake in obesity from the whole body to the cellular/molecular level.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For the exercise studies of leg glucose uptake - "insulin sensitive" group:
- •Sedentary, normal weight, premenopausal women.
- •Sedentary, age-matched normal weight men.
- •Weight stable for two (2) months prior to study.
- •Willing to provide written, informed consent.
- •For the exercise studies of leg glucose uptake - "insulin resistant" group:
- •For the exercise studies of leg glucose uptake - "insulin resistant" group:
- •Upper body obese (UBO) premenopausal women.
- •Age-matched upper body obese (UBO) men.
- •Weight stable for two (2) months prior to study.
- •Willing to provide written, informed consent.
排除标准
- •Age < 18 or > 55 years (premenopausal women and age-matched men).
- •Use of glucose-lowering agents.
- •For female subjects: positive pregnancy test at the time of enrollment or study
- •History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- •Active systemic illness or malignancy.
- •Symptomatic macrovascular or microvascular disease.
研究组 & 干预措施
Lean
Other
Control
干预措施: Exercise (Other)
Obese
Experimental
干预措施: Exercise (Other)
结局指标
主要结局
Skeletal muscle glucose uptake
时间窗: 1 hour
Is exercise induced skeletal muscle glucose uptake different in obese compared to lean adults
次要结局
未报告次要终点
研究者
Michael D. Jensen
Principal Investigator
Mayo Clinic
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Copenhagen, Boston, SydneyInsulin SensitivityType 2 DiabetesInsulin ResistanceNCT04178603University of Copenhagen21
已完成
不适用
Nutrition, Exercise, and Breast Cancer SurvivorshipBreast Cancer SurvivorshipSarcopeniaNCT01151488Baltimore VA Medical Center14
已完成
不适用
Meal Glycaemic Index and Exercise After Gastric BypassRoux-en-Y Gastric BypassObesityNCT03478098Kirstine Nyvold Bojsen-Moeller20
已完成
不适用
Exercise, Glucose Kinetics, and the Incretin EffectType 2 DiabetesNCT01607931Rigshospitalet, Denmark12
已完成
不适用
Myocellular Signalling in Skeletal MuscleExerciseInsulin SensitivityNCT03203317University of Copenhagen8