tACS Treatment for Cognitive Impairments in Methamphetamine Addicts
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- ERP components associated with cognitive function
研究概览
简要总结
- To evaluate the cognitive function of methamphetamine Patients.
- Investigate the pathological mechanism of methamphetamine patients from the aspects of EEG and biology;
- The investigators investigated the effects of transcranial alternating current stimulation (tACS) on cognitive impairments in methamphetamine patients
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis diagnosis of methamphetamine use disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
- •None of participants had mixed use of other drugs
- •None of participants had physical disability
- •None of participants had acute physical or mental illness, hallucinations, acute withdrawal symptoms
- •None of participants were receiving any medical treatment
排除标准
- •Intracranial hypertension
- •Cranial defects
- •Serious physical illnesses (e.g., cardiovascular, liver, kidney, gastrointestinal disorders)
- •Infectious diseases
- •Immune system disorders
结局指标
主要结局
ERP components associated with cognitive function
时间窗: Baseline, week 3
Investigate the ERP components associated with cognitive function of methamphetamine patients using event-related potential analysis
Condition stop signal task
时间窗: Baseline, week 3
Condition stop signal task was used to assess cognitive control function, including proactive control and reactive control.
Functional connection of brain region associated with cognitive function
时间窗: Baseline, week 3
Investigate the functional connection of brain region associated with cognitive function of methamphetamine patients using functional connection analysis
Microstate associated with cognitive function
时间窗: Baseline, week 3
Investigate the microstate associated with cognitive function of methamphetamine patients using microstate analysis
Neural Dynamic Coding of brain region associated with cognitive function
时间窗: baseline, week 3
Investigate the functional connection of brain region associated with cognitive function of methamphetamine patients using multivariate pattern analysis
The effect of oxidative stress system on cognitive function
时间窗: Baseline, week 3
The investigators examined markers of oxidative stress related to cognitive function using bioassay.
The effect of immune system on cognitive function
时间窗: Baseline, week 3
The investigators immune indicators related to cognitive function using bioassay.
The effect of brain derived neurotrophic factor(BDNF) on cognitive function
时间窗: Baseline, week 3
The investigators BDNF indicators related to cognitive function using bioassay.
Genetic mechanism of cognitive function
时间窗: Baseline, week 3
The investigators performed comprehensive genetic testing to explore the genetic mechanism of cognitive function.
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
时间窗: Baseline, week 3
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), which contains 12 subtests for calculating the index scores of delayed memory (including list recall, story recall, figure recall, and list recognition tests), attention (including digit span and coding tests), language (including picture naming and semantic fluency tests), visuospatial/constructional index (including figure copy and line orientation tasks), immediate memory (including list learning and story memory tasks), and global neuropsychological function.
Neural oscillations associated with cognitive function
时间窗: Baseline, week 3
Investigate the neural oscillations associated with cognitive function of methamphetamine patients using time-frequency analysis.
次要结局
- Reverse learning task(Baseline, week 3)
- Beck Depression Scale(Baseline, week 3)
- Barrett impulse Scale(Baseline, week 3)
- Degree of insomnia(Baseline, week 3)
- The Sensitivity to Punishment and Reward Questionnaire(Baseline, week 3)
- Visual analog scale(Baseline, week 3)
- The Desires for Drug Questionnaire(Baseline, week 3)
- Obsessive compulsive drug use scale(Baseline, week 3)
- Obsessive-compulsive inventory(Baseline, week 3)
- Thought Control Ability Questionnaire(Baseline, week 3)
- Thought Suppression Questionnaire(Baseline, week 3)
- Rumination Questionnaire(Baseline, week 3)
- Anger Rumination Questionnaire(Baseline, week 3)
- Beck Anxiety Scale(Baseline, week 3)
- Emotional Regulation Difficulty Scale(Baseline, week 3)
- Aggressive questionnair(Baseline, week 3)
研究者
Xiang Yang Zhang
Professor
Beijing HuiLongGuan Hospital