The Application of Cognitive Rehabilitation Therapy for Amphetamine-type Stimulants Addiction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 1 month , 3 month and 6 months
研究概览
简要总结
The computerized cognitive rehabilitation therapy will be used to treat amphetamine-type stimulant (ATS) addiction.
详细描述
The deficits in executive functions related to prefrontal-striatal circuits play a vital role in ATS addiction and relapse, and proposed computerized cognitive rehabilitation therapy as the novel interventions. Focused on evaluating and training executive functions including working memory, inhibitory control, cognitive flexibility, and congitive bias concerning prefrontal-striatal circuits, neuropsychological tests, electroencephalography tests, magnetic resonance spectroscopy (MRS) and functional MRI will be used to evaluate the therapeutic effect of ATS addiction treatment as well as investigate the mechanisms. The study will be very helpful to develop novel interventions in clinical practice and decrease ATS-related harm for both the patients and their families.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •diagnosed MA dependence in accordance with the fourth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (Association, 2000);
- •more than 9 years of education;
- •aged of 18-60 years old;
- •normal vision, audition and no color blindness;
- •receive no detoxification medications during treatment and
- •right handedness.
排除标准
- •current medical diseases that required hospitalization or regular monitoring;
- •serious physical or neurological illness that required pharmacological treatment affecting cognitive function;
- •history of major psychiatric disorder such as bipolar disorder, schizophrenia, depression and disorders of high comorbidity with substance abuse/dependence;
- •neurological diseases such as stroke, seizure, migraine, head trauma
- •substance dependence other than nicotine, within the past 5 years;
- •intelligence quotient (IQ) <70.
结局指标
主要结局
Change from Baseline Craving for ATS assessed by Visual Analog Scales (VAS) at 1 month , 3 month and 6 months
时间窗: Baseline, 1 month, 3 month and 6 months
evaluate all participants' craving for ATS by Visual Analog Scales (VAS): The scores of the VAS were 0-10 points. 10 points reflect the highest level of individual's craving, and 0 point reflect no craving in patient.
次要结局
- Changing of response inhibition ablility assessed by Balloon Analogue Risk Task (BART)(Baseline, 1 month, 3 month and 6 months)
- Number of participants who relapse(1 month, 3 month and 6 months)
- Cognitive function assessed by CogState Battery (CSB)(Baseline, 1 month, 3 month and 6 months)