Iris Color and Day-Night Changes in the Sympathovagal Ratio
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 621
- 主要终点
- LF/HF ratio
研究概览
简要总结
Iris melanocytes are innervated by parasympathetic and sympathetic nerve endings. Light affects autonomic nervous system activity via the retino-hypothalamic pathway. The hypothesis that the day-to-night variations in the sympatovagal ratio (LF/HF) may differ among individuals with different brown iris patterns was tested.
详细描述
A total of 621 healthy adults, aged between 16 and 50, with brown eyes and not diagnosed with a disease that might affect the autonomous nerve system were included in the study. A digital camera was used to acquire iris photos. Subjects were grouped into iris color groups (2-0 bg, 1-0 bg, 1-1 db, 1-1 lb, 2-0 b, and 1-0 b). Iris photos were analyzed with Picture Color Analyzer RBG software. The Central/Peripheral (R/RGB) ratio was used for objective distinction between the groups. Using 24-h Holter ECG monitoring, the change in the sympathovagal ratio from day (between 07:00 and 23:00 hrs) to night (between 23:00 and 07:00 hrs) was determined with the formula [(Day - Night) LF/HF)/Day LF/HF].
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 16 Years 至 50 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A total of 650 healthy individuals between the ages of 16 and 50 .
排除标准
- •Diseases that could affect the autonomic nervous system; Obesity Obstructive sleep apnea syndrome Hypertension Diabetes mellitus Atrial fibrillation Coronary disease Heart failure Goiter, etc.
结局指标
主要结局
LF/HF ratio
时间窗: one week
low frequency (LF, 0.04-0.15 Hz) and high frequency (HF, 0.16-0.4 Hz) measurements were taken from day and night changes in the heart rate by using the frequency-domain analysis method.
次要结局
未报告次要终点
研究者
Şahbender Koç
MD Cardıologist
Ankara Ataturk Sanatorium Training and Research Hospital