The Effects of Long Term Inhalation of Hypertonic Saline in Subjects With Cystic Fibrosis
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 164
- 主要终点
- Lung function (FEV1, FVC, FEF25-75)
研究概览
简要总结
The effect of long term inhalation of hypertonic saline in subjects with cystic fibrosis on lung function, incidence of respiratory tract infections, quality of life, quantitative microbiology and sputum cytokine profile. The hypothesis is that regular inhalation of nebulised hypertonic saline will have a beneficial effect on lung function and other clinical outcomes with no adverse effects on infection and inflammation in adults and children with cystic fibrosis.
详细描述
The study intervention is nebulised hypertonic (7%) saline (Active) or nebulised normal (0.9%) saline (Control) twice per day for 336 days. At a screening visit, subjects will complete quality of life questionnaires, be questioned regarding their medical history, undergo physical examination and spirometry, and will be requested to provide a sputum sample. The subject is then supervised taking their first dose to ensure the correct procedure is used and there are no adverse effects. The subject then commences taking the trial solution at home, and once a week completes a diary card to monitor factors such as respiratory tract infections and medication use. Subsequent visits are scheduled at Days 28, 84, 168, 252, 334, and 336, at which the same investigation are performed as at the screening visit.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 6 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed diagnosis of CF (sweat tests/genotype)
- •The subject, or their legal guardian for children under 18 years old, must provide written informed consent.
- •The subject must be in stable clinical condition at the time of and for a period of 14 days prior to their recruitment into the study.
- •Age > 6 years old
- •FEV1 > 40% predicted for height, age and gender
- •Proven or anticipated compliance with therapy or study protocol
- •Regular attendee at a Cystic Fibrosis Clinic (> 2 visits per year)
- •Able to reproducibly perform lung function tests (spirometry)
- •Relatively stable nutritional status (< 2 kg weight loss in last 6 months and < 5 kg weight loss in last year)
- •Known to have "normal" (for CF subject) laboratory tests - haematology, biochemistry, immunology, coagulation, etc.
排除标准
- •Requiring home oxygen (pO2 <55mmHg or pCO2 >50mmHg) or assisted ventilation.
- •Considered "terminally ill" or listed for transplantation (either lung or liver). Subjects that are listed for transplant after being enrolled in the trial are eligible to continue in the trial.
- •Subjects colonised with Burkholderia cepacia. However, if a subject becomes colonised with B. cepacia during the trial, they should continue in the trial. Subjects should be considered to be B. cepacia positive if they have had even a single lifetime isolate. In these subjects, spirometry should be measured on a dedicated spirometer.
- •Cigarette smoker.
- •Exposure to investigational drugs within the past 30 days.
- •Major haemoptysis (> 60 mL in a single episode) within the last twelve months.
- •Concurrent illnesses eg. cor pulmonale, clinically significant liver disease (portal hypertension, varices).
- •Known allergy to quinine sulphate, Glucose 6-phosphate dehydrogenase deficiency.
- •Immune thrombocytopaenic purpura.
- •Pregnant or lactating females.
- •At risk females unwilling to use appropriate contraception to prevent pregnancy for the duration of their enrolment in the study.
结局指标
主要结局
Lung function (FEV1, FVC, FEF25-75)
次要结局
- Quantitative microbiology of sputum
- Quality of life
- Pulmonary exacerbations (therapy-defined and symptom-defined)(number and duration)
- Total antibiotic-days
- Absenteeism
- Weight / body mass index
- Aquisition and loss of organisms from sputum
- Cyotkine assays in sputum
- Adverse events