ISRCTN63688695已完成未知
Does vitamin D reduce blood pressure and left ventricular (LV) mass in resistant hypertensive patients with vitamin D insufficiency? A double-blind, placebo-controlled, parallel-group randomised trial
niversity of Dundee0 个研究点目标入组 74 人开始时间: 2008年4月21日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 74
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Aged greater than 18 years, either sex
- •2. Serum 25-hydroxy vitamin D less than 75 nmol/L
- •3. Office blood pressure (BP) greater than 140/90 mmHg despite three or more anti-hypertensives
排除标准
- •1. Hypertension known to be due to a correctable underlying medical or surgical cause
- •2. Estimated glomerular filtration rate less than 40 ml/min (by four variable Modification of Diet in Renal Disease [MDRD] equations)
- •3. Liver function tests (alanine aminotransferase [ALT], bilirubin, alkaline phosphatase) greater than 3 x normal
- •4. Corrected calcium greater than 2.60 mmol/L or less than 2.15 mmol/L
- •5. Known metastatic malignancy or sarcoidosis
- •6. Clinical diagnosis of osteomalacia
- •7. History of renal calculi
- •8. Diagnosis of heart failure with left ventricular systolic dysfunction
- •9. Atrial fibrillation
- •10. Already taking vitamin D supplements. Consumption of fish oils will not be a contra-indication to enrolment
- •11. Unable to give written informed consent
- •12. Pregnant or of childbearing age and not taking reliable contraception
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