EUCTR2008-002681-63-GB进行中（未招募）1 期
DOES VITAMIN D REDUCE BLOOD PRESSURE AND LV MASS IN RESISTANT HYPERTENSIVE PATIENTS WITH VITAMIN D INSUFFICIENCY? - Vitamin D for resistant hypertension
Research and Innovation Services, University of Dundee0 个研究点目标入组 74 人开始时间: 2008年7月16日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 74
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •Age >18 yrs
- •Office BP >140/90 mmHg despite 3 or more antihypertensive agents
- •Serum 25 Hydroxy vitamin D <75nmol/L
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
排除标准
- •Hypertension known to be due to a correctable underlying medical or surgical cause
- •Estimated glomerular filtration rate <40mls/min (by 4 variable MDRD equation)
- •Liver function tests (ALT, Bilirubin, Alkaline phosphatase) >3x normal.
- •Corrected calcium >2.60 mmol/L or <2.15 mmol/L
- •Known metastatic malignancy or sarcoidosis
- •Clinical diagnosis of osteomalacia
- •History of renal calculi
- •Diagnosis of heart failure with left ventricular systolic dysfunction
- •Atrial fibrillation
- •Already taking vitamin D supplements (cod liver oil will be permitted however)
- •Unable to give written informed consent
- •Premenopausal / able to bear children (if female)
- •Contraindications to MRI scanning (severe claustrophobia, pacemaker, metal heart valve, metal in eye, ferromagenetic joint implants or spinal rods, implanted nerve stimulator, middle ear implant)
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