Effect of Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- Chungbuk National University
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to investigate the effect of Transcranial Direct Current Stimulation (tDCS) on appetite control related brain regions.
Detailed Description
Transcranial direct current stimulation (tDCS) is emerging tool for brain modulation in a variety of clinical conditions. In addition, recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity. The investigators aim to assess whether modulation of the dorsolateral prefrontal cortex (DLFPC) using tDCS, modifies behavioral response and brain activity while watching visually presented food cues in obese subjects. Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects. Subjects will perform functional MRI experiments with visual food cues. Questionnaire with behavior measures, body compositions, blood tests will be performed.
Investigators
Hyung Jin Choi
Clinical Assistant Professor
Chungbuk National University
Eligibility Criteria
Inclusion Criteria
- •BMI \> 28 kg/m2
Exclusion Criteria
- •history of brain trauma, epilepsy, or other neurological problems
Outcomes
Primary Outcomes
Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI
Time Frame: Immediately after intervention
3T MR scanner with Echo Planar Imaging(EPI) capability(Magnetom, Siemens Medical System)
Secondary Outcomes
- Behavior outcomes on the visual analog scale(Immediately after intervention)