Effect of Transcranial Direct Current Stimulation (tDCS) on Appetite Control Related Brain Regions
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI
研究概览
简要总结
The purpose of this study is to investigate the effect of Transcranial Direct Current Stimulation (tDCS) on appetite control related brain regions.
详细描述
Transcranial direct current stimulation (tDCS) is emerging tool for brain modulation in a variety of clinical conditions. In addition, recent neuroimaging studies suggest that modifying the activity of brain circuits involved in eating behavior could provide therapeutic benefits in obesity.
The investigators aim to assess whether modulation of the dorsolateral prefrontal cortex (DLFPC) using tDCS, modifies behavioral response and brain activity while watching visually presented food cues in obese subjects.
Subjects will receive tDCS two times, one is active stimulation and the other is sham stimulation. Both stimulations will be separated at least one week and the order of sham and active tDCS will be counterbalanced across subjects.
Subjects will perform functional MRI experiments with visual food cues. Questionnaire with behavior measures, body compositions, blood tests will be performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI > 28 kg/m2
排除标准
- •history of brain trauma, epilepsy, or other neurological problems
结局指标
主要结局
Regional brain activity measured by blood-oxygen-level dependent (BOLD) signal of functional MRI
时间窗: Immediately after intervention
3T MR scanner with Echo Planar Imaging(EPI) capability(Magnetom, Siemens Medical System)
次要结局
- Behavior outcomes on the visual analog scale(Immediately after intervention)
研究者
Hyung Jin Choi
Clinical Assistant Professor
Chungbuk National University