The Efficacy of Application of Platelet-rich Fibrin on Periodontal Clinical Parameters and Gingival Crevicular Fluid Platelet-derived Growth Factor-BB and Periostin Levels
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Periodontitis
- Sponsor
- University of Baghdad
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- clinical parameters
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Determine the efficacy of the non-invasive application of PRF on periodontal clinical parameters(pocket reduction) and the levels of PDGF-BB and Periostin in the gingival crevicular fluid.
Detailed Description
The adjunctive use of PRF with conventional ScRp may improve clinical healing, decrease tissue morbidities such as pain and discomfort, increase patient acceptance, reduce treatment time. Since PRF can be utilized as a safe, natural method to repair tissues at a low cost. Our aim is to evaluate the effectiveness of the non-invasive application of PRF as an adjunct to ScRp in patients with stage III grade B periodontitis through measurements of gingival crevicular fluid levels of PDGF-BB and Periostin before and after treatment and compare it with ScRp alone. A split-mouth procedure will be performed to reduce confounders as possible.
Investigators
Sarah Alrihaymee
Dentist
University of Baghdad
Eligibility Criteria
Inclusion Criteria
- •Systemically healthy patients.
- •Patients with periodontitis.
Exclusion Criteria
- •Medical history of systemic disease: diabetes, pregnancy, or lactation.
- •Previous periodontal treatment for the last 6 months
- •Grade II mobility
- •Smoker or alcoholic patient.
- •Teeth with untreated caries, endodontic lesions
- •Symptoms of recent acute illness e.g., COVID-19 will be excluded as well
Outcomes
Primary Outcomes
clinical parameters
Time Frame: 4 weeks and 3 months
measurements of pocket depth in millimeter at baseline and at the end of study
Secondary Outcomes
- PDGF-BB and periostin level in GCF(4 weeks and 3 months)