The Efficacy of Application of Platelet-rich Fibrin on Periodontal Clinical Parameters and Gingival Crevicular Fluid Platelet-derived Growth Factor-BB and Periostin Levels
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- clinical parameters
研究概览
简要总结
Determine the efficacy of the non-invasive application of PRF on periodontal clinical parameters(pocket reduction) and the levels of PDGF-BB and Periostin in the gingival crevicular fluid.
详细描述
The adjunctive use of PRF with conventional ScRp may improve clinical healing, decrease tissue morbidities such as pain and discomfort, increase patient acceptance, reduce treatment time. Since PRF can be utilized as a safe, natural method to repair tissues at a low cost. Our aim is to evaluate the effectiveness of the non-invasive application of PRF as an adjunct to ScRp in patients with stage III grade B periodontitis through measurements of gingival crevicular fluid levels of PDGF-BB and Periostin before and after treatment and compare it with ScRp alone. A split-mouth procedure will be performed to reduce confounders as possible.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Randomization will be performed by coin toss method
入排标准
- 年龄范围
- 15 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy patients.
- •Patients with periodontitis.
排除标准
- •Medical history of systemic disease: diabetes, pregnancy, or lactation.
- •Previous periodontal treatment for the last 6 months
- •Grade II mobility
- •Smoker or alcoholic patient.
- •Teeth with untreated caries, endodontic lesions
- •Symptoms of recent acute illness e.g., COVID-19 will be excluded as well
结局指标
主要结局
clinical parameters
时间窗: 4 weeks and 3 months
measurements of pocket depth in millimeter at baseline and at the end of study
次要结局
- PDGF-BB and periostin level in GCF(4 weeks and 3 months)
研究者
Sarah Alrihaymee
Dentist
University of Baghdad