Postprandial Hypotension and Insulin Levels

Completed

• Conditions: Postprandial Hypotension; Hypoglycemia

• Registration Number: NCT06657287
• Lead Sponsor: Ankara Yildirim Beyazıt University

Brief Summary

The goal of this observational study is to learn about the relationship between postprandial hypotension and insulin levels in adults. The main question it aims to answer is:

Is the incidence of postprandial hypotension high in patients who undergo mixed meal test?

Is insulin level higher in individuals with postprandial hypotension compared to those without during a mixed meal test?

Patients with postprandial symptoms were scheduled for a mixed meal test, during which plasma glucose, insulin, C-peptide, blood pressure, and heart rate were measured at specific time points.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-03
• Primary Completion: 2024-09-01
• Study Completion: 2024-09-01
• Status Verified: 2024-10
• Study First Submitted: 2024-10-23
• Study First Submitted QC: 2024-10-23
• Last Update Submitted: 2024-10-23
• Study First Posted: 2024-10-24
• Last Update Posted: 2024-10-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 111

Inclusion Criteria

• Adults with postprandial symptoms

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Exclusion Criteria

• Individuals with prediabetes or diabetes,
• Those aged 65 and above,
• Patients using antihypertensive medications or with known hypertension,
• Those with active infections,
• Congestive heart failure,
• Peripheral artery disease,
• Advanced-stage dementia,
• Individuals who could not provide a history or were unable to cooperate,
• Patients using medications that could induce hypoglycemia (oral antidiabetics, insulin, beta-blockers, hydroxychloroquine, bromocriptine, etc.)
• Those with conditions that could cause hypoglycemia (uncontrolled hypothyroidism, adrenal insufficiency, growth hormone deficiency, etc.)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Systolic blood pressure	During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)	mmHg
Blood glucose	During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)	mg/dL
Blood insulin	During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)	uIU/mL

Secondary Outcome Measures

Name	Time	Method
Blood C-peptide	During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)	ng/mL
Diastolic blood pressure	During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)	mmHg
Heart rate	During mixed meal test (baseline, 30., 60., 90., 120., 180., 240., 300. min)	bpm

Trial Locations

Locations (1)

Ankara Bilkent City Hospital; 🇹🇷 Ankara, Çankaya, Turkey