Early Detection of Lung Cancer in the Medically Underserved Population
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Cancer
- Sponsor
- Vanderbilt-Ingram Cancer Center
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Candidate biomarkers of risk or of early diagnosis
- Status
- Active, not recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
This research trial studies the long term follow-up for early detection of lung cancer in current or former smokers. Following up on smokers by collecting and analyzing specimens in the laboratory, performing chest computed tomography (CT) scans, as well as reviewing medical records may help doctors detect lung cancer at an earlier stage.
Detailed Description
PRIMARY OBJECTIVES: I. To provide screening for lung cancer in an underserved and high risk population for lung cancer. II. To collect clinical and demographic information and research bio specimens prospectively on high risk individuals. III. To analyze the association between suspected lung cancer risk factors and outcomes such as pre-malignant lesions and diagnosis of lung cancer. IV. To identify and validate biomarkers that are associated with lung cancer risk factors and premalignant lesions. V. To assess the association between patient characteristics and test results to the genetic and histological characteristics of lung preinvasive lesions and cancers. VI. To describe this high-risk cohort and to identify the patients eligible for future clinical trials (e.g. chemoprevention). OUTLINE: Patients are followed up at 1, 2, 3, 4, and 5 years and undergo collection of sputum, nasal epithelium, buccal epithelium, blood, and urine samples. Patients also undergo pulmonary function tests, chest CT, and review of medical records.
Investigators
Eric Grogan
Associate Professor of Thoracic Surgery
Vanderbilt-Ingram Cancer Center
Eligibility Criteria
Inclusion Criteria
- •Current smoker or former smoker, if former smoker participants must have quit smoking within the past 15 years
- •\>= 30 pack year of smoking history
- •Participant is uninsured
Exclusion Criteria
- •History of diagnosis/treatment of lung cancer in the past 2 years
- •History of head/neck or esophageal cancer in the last 1 year
- •Inability to provide informed consent
Outcomes
Primary Outcomes
Candidate biomarkers of risk or of early diagnosis
Time Frame: Up to 5 years.
Will validate the performance of the candidate biomarkers of risk or of early diagnosis.