Opsin Receptors in Melasma
- Registration Number
- NCT04417348
- Lead Sponsor
- Universidad Autonoma de San Luis Potosí
- Brief Summary
Melasma is a hyperpigmentation disorder that is probably exacerbated by visible light. Opsin receptors (OPN 1, 2, 3, 4 y 5) were described in the skin, being capable of activating melanogenesis induced by visible light. The aim of this study was to evaluate the expression of OPN in melasma skin and its changes following treatment with UV-Vis filter and 0.05% retinoic acid for 12 weeks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 15
Inclusion Criteria
- Patients diagnosed with melasma, of 18 years of age and older, without previous treatment or photoprotection measures within the previous 4 weeks, who had Melasma Activity and Severity Index (MASI) scores higher than 7
Exclusion Criteria
- pregnancy or nursing, menopause, coexistence of other pigmentation conditions, heat exposure, regular exercise, diet restriction, consumption of food supplements or any type of drugs (including anti-inflammatories and hormonal treatments) within the previous 2 months, and women who had given birth within 1 year
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Retinoic Acid Retinoic acid patients with melasma treated with 0.05% retinoic acid plus UV-Visible light filter Sunscreen Retinoic acid patients with melasma treated with UV-Visible light filter alone
- Primary Outcome Measures
Name Time Method MASI score 3 months Melasma Activity and Severity Index
- Secondary Outcome Measures
Name Time Method Opsin receptors 3 months Relative Expression of the opsin receptors by RT-qPCR
Trial Locations
- Locations (1)
Dermatology Department. Hospital Central "Dr. Ignacio Morones Prieto"
🇲🇽San Luis Potosí, Mexico