asal irrigation with licorice extract to treat inflammation of the nose and sinuses

Not Applicable

Completed

• Conditions: Ear, Nose and Throat; allergic rhinitis, non-allergic rhinitis, chronic rhinosinusitis with polyposis, chronic rhinosinusitis without polyposis, nasopharyngeal carcinoma post-radiotherapy complicated with sinusitis

• Registration Number: ISRCTN51425529
• Lead Sponsor: Chiayi Chang Gung Memorial Hospital

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33857594/ Allergic rhinitis (added 12/08/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36447209/ investigating nasal polps in a small number of treated patients (added 14/12/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-04-17
• Study Completion: 2021-10-31
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Diagnosis of allergic or non-allergic rhinitis
2. Diagnosis of chronic rhinosinusitis with or without nasal polyps

Exclusion Criteria

1. Aged <20 years
2. Antihistamine or corticosteroid (oral form or intranasal spray) use within 4 weeks of the intervention
3. Pregnancy
4. Planned sinonasal surgery within 4 weeks of the intervention
5. Allergy to licorice.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Improvement in nasal obstruction measured by TSS (0-3), VAS (0-100) and SNOT22 at 0, 2 and 4 weeks<br> 2. Improvement in rhinorrhea measured by TSS (0-3), VAS (0-100) and SNOT22 at 0, 2 and 4 weeks<br> 3. Improvement in sneezing measured by TSS (0-3), VAS (0-100) and SNOT22 at 0, 2 and 4 weeks<br> 4. Improvement in itchy nose measured by TSS (0-3), VAS (0-100) and SNOT22 at 0, 2 and 4 weeks<br> 5. Improvement in postnasal drip measured by TSS (0-3), VAS (0-100) and SNOT22 at 0, 2 and 4 weeks<br> 6. Improvement in sleep quality measured by TSS (0-3), VAS (0-100) and SNOT22 at 0, 2 and 4 weeks<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. Nasal condition measured by nasal endoscopic examination, which is scored by using Lund Kennedy endoscopic scoring system, at 0, 2 and 4 weeks<br> 2. Nasal resistance measured using acoustic rhinometry at 0, 2 and 4 weeks<br> 3. Analysis of cytokines in the nasal discharge at 0, 2 and 4 weeks<br>