Aging, Aged Garlic, Vascular Function and Muscle Oxygenation

Not Applicable

Completed

• Conditions: Dyslipidemias; Aging; Hypertension; Abdominal Obesity
• Interventions: Dietary Supplement: Aged Garlic Extract; Other: Placebo

• Registration Number: NCT04008693
• Lead Sponsor: Universidade Federal do Rio de Janeiro

Brief Summary

The number of elderly individuals affected by cardiovascular diseases has been increasing in our country. Garlic (Allium sativum) has been associated with decrease of reactive species of oxygen, hypertension, high cholesterol, platelet aggregation, blood coagulation and especially cardiovascular diseases. The present study evaluated the effects of a garlic supplementation on vascular function and blood pressure in the elderly at cardiometabolic risk. Twenty-eight elderly individuals were submitted to an ingestion of four capsules of an aged garlic extract (KYOLIC® Aged Garlic Extract™). Muscle oxygenation and function were measured 180 min after interventions. Urinary thiosulfate, blood nitrate, nitrite, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were measured at baseline and 180 min after interventions.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-06-19
• Study First Submitted QC: 2019-07-03
• Study First Posted: 2019-07-05
• Study Start: 2019-08-26
• Primary Completion: 2020-01-30
• Study Completion: 2020-03-30
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-15
• Last Update Posted: 2020-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• Cardiometabolic risks
• Cardiovascular diseases

Exclusion Criteria

• Cancer;
• HIV positive;
• Alcohol or drug abuse within the past 6 months previous the visit 1;
• Garlic allergy;

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Kyolic® Hi-Po Formula - Kyolic	Aged Garlic Extract	Aged garlic extract
Placebo	Placebo	Maltodextrin

Primary Outcome Measures

Name	Time	Method
Near infrared spectroscopy 1	180 minutes after nutritional intervention	microvascular endothelial function
High performance liquid chromatography 2	Baseline and 180 minutes after nutritional intervention	Urinary thiosulfate concetrations
High performance liquid chromatography 1	Baseline and 180 minutes after nutritional intervention	Urinary nitrate concentrations
Near infrared spectroscopy 2	180 minutes after nutritional intervention	muscle oxygenation saturated assessment

Trial Locations

Locations (1)

Universidade Federal do Rio de Janeiro - Campus Macaé; 🇧🇷 Macaé, Rio De Janeiro, Brazil