Effect of high frequency rTMS on negative symptoms and cognitive functioning in schizophrenia
- Conditions
- - schizophrenia- negaive symptoms- transcranial magnetic stimulation- TMS- cognitive functioning
- Registration Number
- NL-OMON25191
- Lead Sponsor
- niversity Medical Center Groningen (UMCG)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
1. Participants must be 18 years or older.
2. They must be diagnosed with schizophrenia and the diagnosis must be confirmed by a standardised psychiatric assessment, the Schedules for Clinical Assessment in Neuropsychiatry (SCAN 2.1).
Exclusion Criteria
1. Exclusion criteria include rTMS and MRI contraindications (e.g. a personal or family history of epileptic seizures, history of brain surgery, intracerebral or pacemaker implants, inner ear prosthesis or other metal prosthetics/implants).
2. Neurological disorders, a head injury with loss of consciousness in the past.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcome of the study is a significant decline of negative symptoms and cognitive dysfunctioning after bilateral high frequency rTMS treatment of the DLPFC.
- Secondary Outcome Measures
Name Time Method The secondary outcome of the study is increased cortical activation in the DLPFC after rTMS treatment, measured through a fMRI study.