Evaluation of Retinal and Choroidal Microvascular Structures: Comparison With Three Trimesters of Healthy Pregnant Women and Healthy Non-pregnant Women Using Optical Coherence Tomography Angiography
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pregnancy Related
- Sponsor
- Akdeniz University
- Enrollment
- 86
- Locations
- 1
- Primary Endpoint
- Choroidal thickness
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
During pregnancy many physiological changes and adaptations occur.Hormonal, hematological and hemodynamic changes are responsible for most of the ocular adaptations.We are planning to compare the choroid and retinal blood flow values and choroidal thickness of pregnant women and healthy non pregnant women with optical coherence tomography and optic coherence tomography angiography
Detailed Description
During pregnancy many physiological changes and adaptations occur such as pulmonary, renal, endocrinological, haematological and visual system changes are happening. In previous studies, retinal and choroidal pregnancy-related changes in blood flow and choroidal thickness have been demonstrated. Optical coherence tomography angiography (OCTA) detects the contrast of motion in the blood flow, detecting the capillary of the retina and choroid. It is a new functional method that visualizes the retinal networks and outer retina without using dyes.It is a non-invasive method that provides volumetric angiography information. In this study evaluation of the variability of choroidal and retinal blood flow changes and choroidal thickness, between trimesters of pregnancy and the non-pregnant control group is planned. Choroid and Retinal Blood Flow Values and Choroidal thickness in 41 pregnant women in the first trimester and it would be repeated at second and third trimesters. We compare measured values between trimesters and 45 healthy non-pregnant women.
Investigators
Çisil Erkan Pota
Medical Doctor
Akdeniz University
Eligibility Criteria
Inclusion Criteria
- •Healthy pregnant women Age \> 18 years
Exclusion Criteria
- •Systemical disease such as diabetes mellitus or hypertension
- •Refractive error; spherical equivalence \> 4 diopters
- •Ocular disease or surgery history
Outcomes
Primary Outcomes
Choroidal thickness
Time Frame: 40 weeks
Choroidal thickness is measured by optical coherence tomography
Retinal thickness
Time Frame: 40 weeks
Retinal thickness is measured by optical coherence tomography
Secondary Outcomes
- Retinal nerve fiber layer thickness(40 weeks)
- Retinal vascular density(40 weeks)
- Foveal avascular zone(FAZ) area measurement(40 weeks)
- Ganglion cell layer measurement(40 weeks)