Change in Corneal Biomechanics During Pregnancy
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Change in corneal thickness
研究概览
简要总结
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
详细描述
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
Measurement of intraocular pressure is highly dependant on corneal properties. With the Corvis ST device by Ocular Inc. it is possible to measure intraocular pressure and investigated corneal biomechanics. The aim of this study is therefore to compare corneal biomechanical properties during the third trimester with corneal biomechanical properties at 3 months after delivery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •age 18 to 38 yo
- •uncomplicated singleton pregnancy
排除标准
- •any history of ocular disease or surgery other than conjunctivitis, especially no history of glaucoma or corneal disease
- •systemic diseases, i.e. diabetes, hypertension, collagenase
- •current contact lens wear
- •before pregnancy taking any systemic or ocular medications
结局指标
主要结局
Change in corneal thickness
时间窗: at 3 month post delivery compared to during third trimester of the pregnancy
Change in corneal thickness (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed.
Change in Intraocular pressure
时间窗: at 3 month post delivery compared to during third trimester of the pregnancy
Change in intraocular pressure (in millimeters of mercury, mmHg) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed.
Change in Deformation Amplitude
时间窗: at 3 month post delivery compared to during third trimester
Change in Deformation Amplitude (in millimeters) at 3 month post delivery compared to during third trimester will be assessed.
Change in Corneal Velocity
时间窗: at 3 month post delivery compared to during third trimester of the pregnancy
Change in Corneal Velocity (in meters/second) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed.
Change in Applanation Length
时间窗: at 3 month post delivery compared to during third trimester of the pregnancy
Change in Applanation Length (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed.
次要结局
未报告次要终点