Fecal microbiota tRAnspLantation uSed TO improve postpraNdial bacterIAl translocation;<br>the RALSTONIA study. - RALSTONIA study

Academisch Medisch Centrum0 个研究点目标入组 36 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

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•Metabolic syndrome patients:
•- Caucasian
•- BMI >25 kg/m2
•- At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose *5.6 mmol/l, triglycerides *1.7 mmol/l, waist-circumference >102 cm, HDL-cholesterol 1.04 mmol/l, blood pressure *130/85 mmHg
•- Scheduled for laparoscopic cholecystectomy or laparoscopic gastric bypass;Lean donors:
•- BMI 18,5-25 kg/m2

•Metabolic syndrome patients:
•- A history of cardiovascular event (cerebrovascular accident, myocardial infarction or pacemaker implantation)
•- Use of any medication including proton pump inhibitors and antibiotics in the past three months
•- (Expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count < 240/mm3)
•- Type 2 diabetes mellitus
•- Smoking;Lean donors:
•- Use of any medication including proton pump inhibitors and antibiotics in the past 3 months
•- Type 2 diabetes mellitus
•- Diarrhea
•- Cholecystectomy
•- HIV, HAV, HBV, HCV, active CMV, active EBV
•- Unsafe sex practice (questionnaire)
•- Illicit drug use
•- Presence of fecal bacterial pathogens (Salmonella, Shigella, Campylobacter, Yersinia) or parasites
•- Positive C. difficile stool test

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