JPRN-UMIN000021977已完成未知
Alternation in glucagon secretion by dietary intake after administration of sodium glucose transporter-2 inhibitor. - Alternation in glucagon secretion by Sodium glucose transporter-2 inhibitor
Kitasato University, School of Medicine0 个研究点目标入组 19 人开始时间: 2016年5月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 19
研究概览
简要总结
Primary endpoint There was no significant change in glucagon fluctuation before and after Luseogliflozin administration. Secondary endpoint 1. GLP-1 secretion during meal tolerance test increased after Luseogliflozin administration but GIP secretion did not change. 2. The secretion ratio of glucagon to insulin, GLP-1, and GIP during meal tolerance test were not changed. 3. HOMA-R and Matsuda index were both improved, as were HOMA-beta and Disposition index.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 80years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. A patient suffering from acute disease 2. In case of malignacy 3. Renal dysfunction (estimeted GFR <60ml/min) 4. Liver dysfunction (AST >100U/l, ALT >100U/l) 5. Pregnant or possibility of pregnant 6. Lactating mothers 7. A patient suffering from endocrine disorders 8. A patient administrated any drugs affect glucose metabolism 9. Diabetic patients who have taken any hypoglycemic agents include SGLT-2 inhibitor in proximate 6 months 10.A patient undergoing or having history of treatment for ischemic heart disease 11.Chronic heart failure (NYHA class 2 or worse) 12.A patient undergoing or having history of treatment for cerebro-vascular disease 13.A patient undergoing or multiple (3 times or more) history of urinary or genital tract infection 14.A patient accompanied with severe diabetic retinopathy, nephropathy, neuropathy 15.A patient in hyperglycemic crisis or accompanied with marked symptom of hyperglycemia 16.Taking diuretics 17.Correspond to contraindication of Luseogliflozin
研究者
相似试验
已完成
不适用
Alternation in glucagon secretion associated with progression of glucose intolerance.normal glucose tolerance, impaired glucose metabolism, Type 2 diabetes mellitus (non-insulin dependent)JPRN-UMIN000016133Kitasato University School of Medicine53
已完成
不适用
Comparison of fluctuation of glucagon after oral glucose, protein or lipid intake in healthy Japanese adult.healthy Japanese adultJPRN-UMIN000026502Department of Endocrinology, Diabetes and Metabolism, Kitasato University, School of Medicine10
招募中
不适用
Study of glucagon response and its association with glycemic control and variability after administration of ipragliflozin as an adjunctive to insulin treatment in patients with type 1 diabetes (Suglat-AID): a single-arm, multicenter, open-label,prospective exploratory trialtype 1 diabetesJPRN-UMIN000039635agasaki University Hospital24
已完成
不适用
Evaluation of change in blood glucagon levels in response to orally glucose loading and food intakeDiabetes mellitusJPRN-UMIN000027852Gunma University70
已完成
不适用
Alternation in glucagon secretion by Sodium glucose transporter-2 inhibitorType2 diabetes mellitusType2 deabetes mellitusC18.452.394.750.149JPRN-jRCTs031190010Ichikawa Raishi20