Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling
- Conditions
- Aphasia
- Interventions
- Behavioral: Semantic Feature Analysis (SFA)
- Registration Number
- NCT02916524
- Lead Sponsor
- Boston University Charles River Campus
- Brief Summary
The purpose of this investigation is to implement a computational model that can predict and optimize training and cross-language generalization patterns for bilingual persons with aphasia (BPA). The proposed work will determine the best possible treatment program for each individual patient even before they are rehabilitated. In addition, the computational model allows specification of variables such as age of acquisition, language exposure/proficiency, impairment and their systematic influence on a range of language rehabilitation outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 48
- Any number of years of education
- Bilingual: speaking both Spanish and English (or Chinese and English) with any degree of language proficiency prior to stroke
- Aphasia secondary to a left-hemisphere stroke (diagnosed by a neurologist on the basis of clinical CT/MRI imaging or medical reports)
- Aphasia resulting from stroke or dementia
- Naming deficits must be present with concurrent lexical/semantic impairment
- Visual and auditory acuity sufficient for all assessment and treatment procedures
- Ability to understand study and follow study procedures for the entire length of the study
- Premorbid history of speech/language disorder
- Proficient in more than just Spanish and English (or Chinese and English)
- Overt, behaviorally noticeable, attentional limitations that interfere with completing the experimental tasks
- Active medical disease that may compromise participation (e.g., cancer undergoing acute treatment, unstable diabetes, renal or hepatic insufficiency, fluctuating systemic immunological disease such as systemic lupus erythematosis, etc.)
- Currently taking medications that are known to exert significant effects on cognitive processes, such as neuroleptics, steroids, anticholinesterase inhibitors, etc.
- Current drug or alcohol use or dependence that would interfere with adherence to study requirements, in the opinion of the principal investigator
- Inability or unwillingness of individual to give written informed consent
- Diagnosed with mental illness other than active depression
- Neurological condition other than that which resulted in aphasia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Model-based Semantic Feature Analysis (SFA) Semantic Feature Analysis training will be provided in the language that was selected by the computational model. Model-opposite Semantic Feature Analysis (SFA) Semantic Feature Analysis training will be provided in the language opposite to that which was selected by the computational model.
- Primary Outcome Measures
Name Time Method Word Retrieval Accuracy in both languages Through study completion, an average of 10 weeks Accuracy of naming of pictured treated and untreated items in both languages will be assessed in probes conducted separate from treatment. Probes were conducted repeatedly throughout the study, from baseline (prior to treatment) to the end of treatment. All naming responses were scored using as correct or incorrect. A percentage accuracy was calculated for each set of items for every probe session. Baseline probe scores were compared to end of treatment probe scores to obtain individual effect sizes for each sets of items for each participant (i.e., several effect sizes were calculated for each participant).
- Secondary Outcome Measures
Name Time Method Verbal fluency task (COWAT) in both languages Week 1 and up to 10 weeks Assesses general fluency
Psycholinguistic assessments of language processing in aphasia (PALPA) in both languages Week 1 and up to 10 weeks Reading single words and understanding spoken words
Bilingual Aphasia Test (BAT) B and C in both languages Week 1 and up to 10 weeks Assesses each of the languages of a bilingual or multilingual individual with aphasia
Boston Naming Test (BNT) in both languages Week 1 and up to 10 weeks Naming pictured items
Western Aphasia Battery (WAB) in both languages Week 1 and up to 10 weeks Assesses the levels of impairment of aphasia
Pyramids and Palm Trees Test (PAPT) 3 pictures version Week 1 and up to 10 weeks Assesses semantic processing ability
Cognitive Linguistic Quick Test (CLQT) in both languages Week 1 and up to 10 weeks Assesses the contribution of cognitive deficits to language dysfunction
Category fluency task in both languages Week 1 and up to 10 weeks Assesses category fluency
Aphasia Bank Week 1 and up to 10 weeks Assesses discourse
Communication Effectiveness Index (CETI) for both languages Week 1 and up to 10 weeks Determines communication effectiveness by proxy
Trial Locations
- Locations (3)
Boston University Sargent College
🇺🇸Boston, Massachusetts, United States
San Francisco State University
🇺🇸San Francisco, California, United States
Austin Speech Labs
🇺🇸Austin, Texas, United States