Magnesium Supplementation to Prevent Bone Loss
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 74
- 试验地点
- 2
- 主要终点
- Biomarkers bone turnover (P1NP and CTX)
研究概览
简要总结
Extreme magnesium deficiency is known to have an impact on the synthesis, secretion and/or action of calcium regulating hormones. Many older adults are at risk for less severe magnesium deficiency, since the majority of adults receive less than the Recommended Daily Allowance of magnesium. We hypothesize that magnesium supplementation will have a beneficial effect on calcium regulating hormones and markers of bone turnover.
详细描述
This is a 12 month randomized, double-blind, placebo-controlled study of magnesium supplementation. Our hypothesis was that magnesium supplementation would decrease bone turnover markers and alter calcium-regulating hormones: parathyroid hormone and 1, 25 dihydroxyvitamin D.
Male and female adults over 55 without with a T-score at the hip above -2 are randomized to magnesium 250 mg BID or identical placebo BID. At baseline, all participants had a bone mineral density (BMD) by DXA scan at the hip and spine, blood biomarkers of bone resorption and formation, and calcium regulating hormones. Participants were followed for 12 months, with repeat measurement of calcium regulating hormones and bone turnover markers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy ambulatory men and women between the ages of 55-75 years
- •Women at least 5 years after menopause
排除标准
- •Inability to give informed consent in accordance with institutional guidelines
- •Creatinine greater than or equal to 2 mg/dl, since magnesium is excreted by the kidneys
- •Diarrhea or loose frequent stools (> 2 a day) at least 3 days/ week in last 3 months
- •Use within 12 months of estrogen, bisphosphonates, calcitonin, or raloxifene
- •Current use of loop diuretics
- •Use within 12 months of corticosteroids
- •History of hyperparathyroidism, hyperthyroidism, or osteomalacia within past 12 month
- •Vitamin D deficient as measured by 25-hydroxyvitamin D outside of the normal range
- •Magnesium supplementation of greater than 250 mg/day
- •Calcium supplementation of greater than 1500 mg/day
- •Conditions which, in the opinion of the investigator, would interfere with the evaluation of BMD at the spine including severe scoliosis, osteophytosis and lumbar fusion
- •Bilateral hip replacement
- •BMD at the lumbar spine L2-L4 of less than 0.859g/cm2 for women or 0.895 g/cm2 in men; or total hip less than 0.698 g/cm2 for women or 0.731 g/cm2 for men; or femoral neck less than 0.627 g/cm2 for women or 0.658 g/cm2 for men This represents a T-score of less than -2 at each site
- •High serum calcium on screening blood test
结局指标
主要结局
Biomarkers bone turnover (P1NP and CTX)
Calcium regulating hormones (PTH and 1,25 dihydroxyvitamin D)
次要结局
- Change in RBC magnesium
- Change in BMD at the spine, femoral neck and total hip by DXA