A study of below knee serial casting for calf contracture in ambulant boys with Duchenne muscular dystrophy.

Not Applicable

• Conditions: Duchenne muscular dystrophy; tendoachilles contracture; Neurological - Other neurological disorders; Human Genetics and Inherited Disorders - Other human genetics and inherited disorders

• Registration Number: ACTRN12611000083998
• Lead Sponsor: Royal Children's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-01-24
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Aged 4 years or greater
- Independently ambulant over a distance of at least 75 metres and able to complete a 6 minute walk test
- With a measurable calf contracture (ie maximum PROM ankle dorsiflexion less than or equal to 0 degrees with the knee fully extended)
- With full passive knee extension or a knee flexion contracture less than 10 degrees
- With quadriceps lag less than 5 degrees
- With hip and knee flexor and extensor strength of at least grade 4 plus on manual muscle testing (Mendell and Florence 1990).
- Who are cognitively and emotionally able to cope with the treatment
- Whose family supports the treatment and undertakes to complete the protocol

Exclusion Criteria

- Aged under 4 years
- unable to ambulant 75 metres and unble to complete a 6 minute walk test
- passive knee extension or a knee flexion contracture greater than or equal to 10 degrees
- With quadriceps lag greater than 5 degrees
- With hip and knee flexor and extensor strength of less than grade 4 plus on manual muscle testing (Mendell and Florence 1990).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduce calf contracture and achieve a passive range of ankle dorsiflexion (DF) of at least plantigrade (90 degrees) assesed using goniometry.[baseline, 1month, 3months, 6months, 9months, 12months]

Secondary Outcome Measures

Name	Time	Method
Improve gait parameters including heel contact assessed with GAITRite electronic walkway, 6 minute walk test and timed functional tests.[baseline, 1month, 3months, 6months, 9months, 12months];Maintain or improve level of motor function assesed with North Star Ambulatory Assessment and timed functional tests.[baseline, 1month, 3months, 6months, 9months, 12months]