In utero sonographic assessment of calve muscles in fetuses with clubfeet (pes equinovares) and fetuses with no structural anomalies with follow-up after birth.

Conditions: Clubfeet
Pes equinovares
10028396
10028920

Registration Number: NL-OMON48647

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 70

Inclusion Criteria

- Patient should be over the age of 18 years
- Singleton pregnancy
- All fetuses with unilateral or bilateral idiopathic pes equinovares referred
to, or presenting at, Amsterdam UMC for targeted ultrasound examination around
20 weeks of gestation.

Exclusion Criteria

- Patients under 18 years
- Twin pregnancy
- Multiple congenital anomalies
- An- or oligohydramnios
- History of uterus anomalies
- Septa in the uterine cavity during this pregnancy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary objective of the study is to examine muscle atrophy in fetuses with<br /><br>single or bilateral PEV, in comparison to a normal population by measuring the<br /><br>circumference of the upper and lower legs. The measurements will be performed<br /><br>prenatally at 20 weeks of gestation and around 28-30 weeks of gestation,<br /><br>neonates will be examined directly after birth and 6 weeks post-partum. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The length of the bones of the upper- and lower extremities and the length of<br /><br>the feet will be measured to examine if there is a difference in the length of<br /><br>the bones in fetuses affected with single or bilateral IPEV in comparison to<br /><br>the normal population. </p><br>