Neural and Cognitive Mechanisms of Depression and Anxiety: a Multimodal MRI Study

University of Electronic Science and Technology of China1 site in 1 country150 target enrollmentJune 2015

ConditionsDepression

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Depression
Sponsor: University of Electronic Science and Technology of China
Enrollment: 150
Locations: 1
Primary Endpoint: Brain structural and functional changes in patients
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To explore the neural and cognitive mechanisms of depression (including unipolar depression and Bipolar disorder) and anxiety using multimodal MRI techniques.

Registry

clinicaltrials.gov

Start Date

June 2015

End Date

January 2017

Last Updated

9 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University of Electronic Science and Technology of China

Responsible Party

Principal Investigator

chenhuafu

professor

University of Electronic Science and Technology of China

Eligibility Criteria

Inclusion Criteria

•Age range from 16 to 55 years old.
•All patients were interviewed by two experienced psychiatrists using the Structured Clinical Interview for DSM-IV (patient edition)

Exclusion Criteria

•Schizophrenia, mental retardation or personality disorder, any history of loss of consciousness, substance abuse, serious medical or neurological illness.
•Subjects with contraindications to MRI

Outcomes

Primary Outcomes

Brain structural and functional changes in patients

Time Frame: one time point

Structure and function changes in patients will be assessed by Voxel-based morphometry analysis for structural changes, as well as Regional homogeneity, Amplitude of lowfrequency fluctuation, etc, for functional changes.