Brain Imaging of Psychotherapy for Depression

Not Applicable

Completed

• Conditions: Major Depressive Disorder
• Interventions: Behavioral: Brief Behavioral Activation Treatment for Depression

• Registration Number: NCT00609453
• Lead Sponsor: University of North Carolina, Chapel Hill

Brief Summary

The goal of the proposed research is to examine the neural correlates of depressive symptom reduction in individuals with major depressive disorder using functional magnetic resonance imaging (fMRI), and to compare results to those obtained from a nondepressed control group.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-10
• Primary Completion: 2008-01
• Study Completion: 2008-01
• Study First Submitted: 2008-01-24
• Study First Submitted QC: 2008-02-06
• Study First Posted: 2008-02-07
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-05
• Last Update Posted: 2012-10-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• For group 1: Diagnosis of current depression and no other current Axis I psychiatric disorder
• For group 1: Hamilton Depression Rating Scale score of 15 or greater

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Exclusion Criteria

• A history of serious head injury or neurological disease or psychosis
• Current use of psychoactive medications
• Factors that could affect MRI safety including current or planned pregnancy
• For group 2: current Axis I psychiatric disorder, as assessed by structured clinical interview

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
1	Brief Behavioral Activation Treatment for Depression	Individuals with major depressive disorder receiving therapy

Primary Outcome Measures

Name	Time	Method
Functional Magnetic Resonance Imaging	twice in 12 weeks
Hamilton Depression Inventory	three times over 12 weeks

Trial Locations

Locations (1)

Duke-UNC Brain Imaging and Analysis Center; 🇺🇸 Durham, North Carolina, United States