Using Neuroimaging to Investigate Neurobiological Correlates of Treatment Resistance Associated With Co-morbid Anxiety in Major Depressive Disorder
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Treatment response-the Quick Inventory of Depressive Symptomatology: Clinician Rated (QIDS-SR)
研究概览
简要总结
The purpose of this neuroimaging study is to investigate the brain correlates of Major Depressive Disorder with anxiety symptoms as well as potentially identify predictors of treatment outcome.
详细描述
The purpose of this study is to test whether the structural and functional connectivity between the dorso-lateral prefrontal cortex (DLPFC) and amygdala will decline as symptoms of co-morbid anxiety (Anxiety Factor Score) increase in patients with MDD. This decrease in connectivity will also account for decrease in treatment response. The structural connectivity will be assessed using Diffusion Tensor Imaging (DTI) and the functional connectivity will be assessed using resting state BOLD fMRI.We propose to use the fMRI and DTI to identify biological markers that are associated with treatment response in a cohort of patients with a spectrum of Anxiety Factor Scores.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Competent to give informed consent
- •Diagnosis of Major Depressive Disorder
- •Males and females
- •Ages 18-50 years old
- •All races and ethnicities
- •Able to read, speak, and understand English*
排除标准
- •History of psychiatric illness except Major Depressive Disorder, Generalized Anxiety Disorder, Social Phobia, or Specific Phobia
- •Alcohol or substance abuse within the last 6 months or alcohol or substance dependence within the last year
- •Diagnosis of an organic brain disease
- •Serious unstable medical illness
- •History of serious head injury
- •Unsafe or unable to have an MRI or previous inability to tolerate MRI
- •Pregnancy or breast feeding
结局指标
主要结局
Treatment response-the Quick Inventory of Depressive Symptomatology: Clinician Rated (QIDS-SR)
时间窗: 8 weeks
次要结局
- Degree of comorbid anxiety-a subset of the Hamilton Rating Scale for Depression will be used to determine the anxiety/somatization factor scores(8 weeks)