Clinical study on significant antihypertensive effects of two Rg3 enriched Korean ginsengs (vitamin C-treated white ginseng and enzyme-treated red ginseng) on moderate hypertensive subject: Randomized, double-blind, placebo-controlled, and long-term human trial

Dankook Univeristy Hospital0 个研究点目标入组 90 人开始时间: 待定最近更新: 2023年5月30日

试验速览

The two test groups (the vitamin ginseng group and the enzyme red ginseng group) statistically significantly reduced SBP at 12 weeks compared to the control group (vitamin ginseng p<0.001, enzyme red ginseng p<0.001) 2) In the case of DBP, both the vitamin ginseng and the enzyme red ginseng groups showed a significant reduction effect at the point of 12 weeks (vitamin ginseng p=0.012, enzyme red ginseng p=0.001) 3) Compared to the control group, the two test groups (the vitamin ginseng group and red ginseng group) significantly lowered arterial pressure at 12 weeks (vitamin ginseng p<0.001, enzyme red ginseng p<0.001) 4) There were no serious adverse event in both the vitamin ginseng and the enzyme red ginseng extracts, and other adverse event showed no significant difference from the control group Both the vitamin ginseng and the enzyme red ginseng were effective in lowering SBP, DBP and arterial blood pressure at 12 weeks of administration compared to placebo. Nitric oxide(NO) and hs-CRP levels did not show significant changes. There were no significant or additional adverse reactions in both the vitamin ginseng and the enzyme red ginseng extracts.

•1. Men and women aged between 20 and 70 years.
•2. Participants for whom after resting 5 min in a sitting position, the average SBP measured twice with a 2-minute interval was 125-245 mmHg,
•or the DBP was in the range of 80-95 mmHg, except for those who required medication. For those with stage 1 hypertension, the SBP range was
•140-145 mmHg or the DBP was 90-95 mmHg.
•3. People who voluntarily decided to participate and agreed in writing to abide by the precautions after hearing and fully understanding the detailed
•explanation of this study.

•1. Participants having a history of hypersensitivity and a habit of ginseng and red ginseng consumption.
•2. Those who have taken blood pressure-lowering drugs or blood circulation improving drugs (ginkgo leaf extract, aspirin, etc.).
•3. Participants who have taken herbal medicines, peptides-containing medicines/food, oral steroids, or hormones within the last one month.
•4. Participants who are under treatment for alcoholism or being treated for thyroid dysfunction.
•5. Diabetic patients who are currently taking medications.
•6. Those who underwent surgery within the last six months.
•7. People having severe renal or hepatic dysfunction.
•8. Those who have had surgery that may affect drug absorption, such as gastrectomy.
•9. Pregnant, lactating, and childbearing women who do not use appropriate contraceptive methods.
•10. Those who have consumed other clinical trial foods or test drugs within the last two months.
•11. Those who have donated blood within the last two months.
•12. Patients with uncontrolled hypertension (160/100 mmHg) or those who are taking new medications due to high blood pressure within the
•last three months.

发起方

Dankook Univeristy Hospital