Comparison between two doses of Dexmedetomidine through Epidural Infusion for Post-operative Pain Relief

Not yet recruiting

Conditions: Intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified,

Registration Number: CTRI/2019/03/017895

Lead Sponsor: Sam Blessy Sheba

Brief Summary: This is a Randomized Double blind-study to compare analgesic efficacy and safety of two different doses of Dexmedetomidine for continuous Epidural post-operative analgesia in lower limb surgeries. Primary outcome is to compare analgesic efficacy in terms of Pain Scores in the first 24 hours postoperatively. The secondary outcome is to compare the safety profile measured by sedation score and hemodynamic parameters up to 48 hours postoperatively and to compare pain scores in the next 24 hours, up to 48 hours postoperatively

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 72

Inclusion Criteria

Patients of both sex undergoing lower limb surgeries under Combined Spinal and Epidural Anaesthesia (CSEA) willing to be included in the study.

Exclusion Criteria

1.Patients with Cardiac pathology 2.Hypertension 3.BMI <18 or >30 kg/m2 4.Known allergy to local anaesthetic infiltration 5.Chronic use of any other analgesics 6.American Society of Anaesthesiologists (ASA) III and above 7.Pregnant patients 8.Refusal for consent.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To compare analgesic efficacy in terms of Pain Scores in the first 24 hours postoperatively.	To compare analgesic efficacy in terms of Pain Scores in the first 24 hours postoperatively.

Secondary Outcome Measures

Name	Time	Method
â€¢To compare safety profile measured by sedation score and hemodynamic parameters up to 48 hours post operatively	â€¢To compare pain scores in the next 24 hours, up to 48 hours postoperatively

Trial Locations

Locations (1): Shri Sathya Sai Medical College and Research Institute
🇮🇳
Kancheepuram, TAMIL NADU, India
Shri Sathya Sai Medical College and Research Institute
🇮🇳Kancheepuram, TAMIL NADU, India
Sam Blessy Sheba
Principal investigator
08870065709
bless_1203@hotmail.com