Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 450
- 试验地点
- 1
- 主要终点
- 30-Second Chair Stand Test (primary outcome for Aim 1)
研究概览
简要总结
Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.
详细描述
The overarching hypothesis is that former athletes, especially those with a prior injury, will have poorer function and health in midlife and that current and former athletes will engage in greater overall and longer bouts of sedentary behavior compared to non-athletes.
Aim 1 will compare function, strength, and cardiometabolic indicators among former athletes with and without prior knee injury and non-athlete controls in midlife (age 40-64). Hypothesis 1 is that former athletes with a prior injury will have the poorest function, muscle strength, and cardiometabolic indicators.
Aim 2 will compare sedentary behavior and physical activity patterns in current (age 18-25) and midlife former athletes to non-athlete controls. Hypothesis 2.1 is that current athletes will have greater sedentary behavior, longer sedentary behavior bouts, and higher levels of moderate-to-vigorous physical activity compared to non-athlete controls. Hypothesis 2.2 is that former athletes in midlife will have greater sedentary behavior, longer sedentary behavior bouts, and lower physical activity levels compared to non-athlete controls.
An exploratory aim will evaluate longitudinally the trajectory of physical activity patterns, cardiometabolic indicators, function, and strength annually in each cohort, comparing how these variables change over time in each subgroup.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 64 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Please see cohorts for specific inclusion/
排除标准
- •Inclusion Criteria:
- •Age 18-25 years OR age 40-64 years
- •Current or former collegiate varsity athlete OR non-athlete control
- •Exclusion Criteria:
- •Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function
- •Pregnancy
- •Lower extremity joint replacement (e.g., hip or knee replacement)
研究组 & 干预措施
Midlife former athletes with a prior knee injury
Inclusion Criteria: Age 40-64 years. Prior participation in a collision, contact, or jumping/cutting/pivoting sport (e.g., baseball, basketball, field hockey, football, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the collegiate varsity level for at least 1 season; history of at least 1 prior traumatic knee injury including but not limited to ACL or PCL rupture and/or reconstruction, medial and/or lateral meniscus tear or surgery, osteochondral defect, and/or intra-articular (i.e., tibiofemoral or patellofemoral) fracture.
Exclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement).
Midlife former athletes without a prior major lower extremity injury
Inclusion Criteria: Age 40-64 years. Prior participation in a collision, contact, or jumping/cutting/pivoting sport (e.g., football, baseball, basketball, field hockey, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the collegiate varsity level for at least 1 season.
Exclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement); prior major lower extremity injury (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation).
Midlife controls
Inclusion Criteria: Age 40-64 years.
Exclusion Criteria: Prior participation in a collegiate varsity sport or professional sport; neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement); prior major lower extremity injury (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation).
Young adult athletes
Inclusion Criteria: Age 18-25 years. Participation in a collision, contact, or jumping/cutting/pivoting sport (e.g., baseball, basketball, field hockey, football, ice hockey, lacrosse, soccer, softball, volleyball, etc.) at the varsity collegiate level.
Exclusion Criteria: Neurologic (e.g., stroke, Parkinson's) and/or degenerative disease that impairs function; current pregnancy; lower extremity joint replacement (e.g., hip or knee replacement).
Young adult controls
Inclusion Criteria: Age 18-25 years.
Exclusion Criteria: Prior or current participation in any collegiate varsity sport; prior major lower extremity injury or surgery (e.g., ACL tear, Achilles tendon rupture, compound ankle or femur fracture, hip dislocation); current participation in competitive sport (e.g., collegiate club sport) more than 3x/week; joint replacement in the lower extremity (i.e., knee or hip replacement); current pregnancy; or neurologic condition (e.g., stroke, Parkinson's) and/or degenerative condition that impairs function.
结局指标
主要结局
30-Second Chair Stand Test (primary outcome for Aim 1)
时间窗: Baseline
Physical function (functional performance) will be evaluated using the 30-Second Chair Stand Test, 6-Minute Walk Test, and Stair Climb Test. The 30-Second Chair Stand Test uses a standard height chair and requires the participant to stand up and sit down as many times as possible in 30 seconds. More completions indicate better physical function.
Sedentary Behavior (primary outcome for Aim 2)
时间窗: Baseline
Physical activity will be monitored continuously using an accelerometer worn for 2 weeks. Physical activity will be classified throughout the day as sedentary, light, moderate, or vigorous using established algorithms. The primary outcome for aim 2 is the mean percentage of waking hours in sedentary behavior.
次要结局
- Strength(Baseline)
- Body Composition(Baseline)
- Stair Climb Test(Baseline)
- Step Counts(Baseline)
- 6-Minute Walk Test(Baseline)
- Body Composition (follow-up)(Follow-up (an average of 1 year post-baseline))
- Cardiovascular Disease Risk(Baseline)
- Sedentary Behavior (follow-up)(Follow-up (an average of 1 year post-baseline))
- 30-Second Chair Stand Test (follow-up)(Follow-up (an average of 1 year post-baseline))
- Strength (follow-up)(Follow-up (an average of 1 year post-baseline))
- Stair Climb Test (follow-up)(Follow-up (an average of 1 year post-baseline))
- Step Counts (Follow-up)(Follow-up (an average of 1 year post-baseline))
- 6-Minute Walk Test (follow-up)(Follow-up (an average of 1 year post-baseline))