DOLORisk: Understanding Risk Factors and Determinants for Neuropathic Pain - Peripheral Physiological Measures as Determinants of Pain Risk
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Electrophysiological pain phenotypes using MEM. Pain biomarker
研究概览
简要总结
This study evaluates peripheral nervous system function using Multiple Excitability Measures (MEM) to obtain "electrophysiological pain phenotypes"
详细描述
Using MEM for peripheral sensory and motor axons we want to identify a set of excitability measures that:
- Correlate with parameters of clinical pain and of pain processing in existing pain patients (cross sectional study), with the aim to obtain an objective Pain Biomarker.
- Predict development of neuropathic pain in susceptible patients (longitudinal study). Neuropathic Pain Predictor for patients:
i. Undergoing surgical procedures associated with a relatively high risk of developing neuropathic pain such as thoracotomy and hernia repair ii. Planning to start chemotherapy with potentially neurotoxic agents such as vincristine
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic peripheral neuropathic pain
- •Painless Patient with risk to develop neuropathic pain (post-surgery, chemotherapy-induced)
排除标准
- 未提供
结局指标
主要结局
Electrophysiological pain phenotypes using MEM. Pain biomarker
时间窗: Single assessment (cross sectional study) at the first and only visit
Correlate with parameters of clinical pain and of pain processing in existing pain patients
Electrophysiological pain phenotypes using MEM. Pain predictor
时间窗: Single assessment at baseline, before any procedure (surgery/chemotherapy)
Predict development of neuropathic pain in susceptible patients
次要结局
未报告次要终点