NL-OMON32451已完成3 期
The effect of treatment with high dose vitamin D on airway inflammation in non-atopic asthma. - Vitamin D in non-atopic asthma
Medisch Centrum Leeuwarden0 个研究点目标入组 58 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 58
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Non-atopic asthma (negative alatop test and pulmonologist's diagnosis of asthma)
- •neutrophilic and/or eosinophilic inflammation in induced sputum (>53% neutrophils and/or >3% eosinophils)
- •Documented reversibility in FEV1 of > 12% predicted OR airway hyperresponsiveness to inhaled methacholine
排除标准
- •Contra-indications regarding vitamin D use: hypercalcaemia, malignancy, sarcoidosis, history of kidneystones.
- •Patients with smoking history of >10 packyears and persistent airflow obstruction (post bronchodilator FEV1<80%pred): excluded if reversibility in FEV1 < 12% predicted OR TLCO<80%pred.
- •Vitamin D use prior to this study.
- •Other pulmonary diseases
- •Vitamin D3 level > 100 nmol/l
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