A Comparative Study of Mammography and Ultrasound for Breast Cancer Screening and Early Diagnosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Breast Cancer Diagnosis
- Sponsor
- Peking Union Medical College Hospital
- Enrollment
- 6000
- Locations
- 1
- Primary Endpoint
- screening yield
- Last Updated
- 5 years ago
Overview
Brief Summary
Improving the early diagnosis of breast cancer can reduce mortality. With mammography as the main tool for screening early breast cancer, the characteristics of dense breast and young onset of disease in Chinese women lowers the efficiency. The aim of this prospective study was to compare which method, x-ray or ultrasound, is more appropriate for screening and early diagnosis of breast cancer in Chinese women.
Detailed Description
Breast cancer has become the most common malignancy in women. Improving the early diagnosis of breast cancer can reduce mortality. Mammography is recommended as the main tool for screening and early diagnosis of breast cancer in the guidelines of European and American countries. However, the characteristics of dense breast and young onset of disease in Chinese women make the screening and early diagnosis strategies of Western countries, which are mainly based on mammography, unsuitable for Chinese women. The aim of this prospective study was to compare which method, x-ray or ultrasound, is more appropriate for screening and early diagnosis of breast cancer in Chinese women.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Informed consent, subjects 35-70 years old, asymptomatic, able to undergo ultrasound and x-ray
Exclusion Criteria
- •Localized breast erythema and ulceration, pregnancy, lactation, after previous breast implantation, already pathologically definite breast cancer patients
Outcomes
Primary Outcomes
screening yield
Time Frame: 3 years
The sensitivity, specificity, positive predictive value, and negative predictive value of the screening methods.
Secondary Outcomes
- cost-effectiveness(3 years)