Investigating the effectiveness of deep brain stimulation in improving reaching movements in people with Parkinson's disease

Not Applicable

• Conditions: Parkinson’s disease; Nervous System Diseases

• Registration Number: ISRCTN15101017
• Lead Sponsor: niversity of Oxford

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-12-20
• Last Update Posted: 3 October 2023
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Patients aged 18 years old and over with Parkinson's disease and deep brain stimulation electrodes implanted

Exclusion Criteria

1. Cognitive impairment (judged by the clinician taking consent as not having the sufficient mental capacity to understand the study and its requirements). This is including anyone who, in the opinion of the clinician taking consent is unlikely to retain the sufficient mental capacity for the duration of their involvement in the study.
2. Severe motor impairment (judged by the clinician taking consent as not having the sufficient motor capacity to perform the motor task in the study)
3. Patients unwilling to briefly withdraw the ongoing medications
4. Severe visual impairment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Motor performance in reaching and finger-tapping movements assessed using the following methods during the study session:<br>1.1. Reaction time measured using the Tablet Drawing Monitor (Artist 22, XP-PEN, Japan) by quantifying the time from Go-cue until the pen moves out of the start point during the reaching movements<br>1.2. Velocity measured using the Tablet Drawing Monitor (Artist 22, XP-PEN, Japan) by dividing the accumulated distance by the time used during the reaching movements<br>1.3 Root-mean-square acceleration measured using a tri-axis accelerometer during the finger-tapping movements<br>2. Resting tremor severity measured using an accelerometer during the finger-tapping movements<br>3. Stimulation on time compared across different stimulation conditions during the reaching and finger-tapping tasks. The stimulation on/off time will be recorded automatically by the C++ program

Secondary Outcome Measures

Name	Time	Method
1. Modulations in subthalamic nucleus brain oscillations by movement and different stimulation protocols measured from the recorded bipolar LFP signals during the reaching movements during the study session<br>2. Association between changes in brain oscillations and belabour measured using linear mixed effect modelling during the reaching movements during the study session