Deep Brain Stimulation in Chronic Treatment refractory Drug Dependence: A Pilot Study

• Conditions: treatment resistant drug dependence; untreatable addiction; 10021563

• Registration Number: NL-OMON35020
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 8

Inclusion Criteria

- Chronic course of substance use disorder: minimal duration of 5 years of DSM-IV diagnosis heroin and/or cocaine dependence
- Being treatment refractory despite treatment programs
- Severe dependence: heroin/cocaine use at least 15 days in last month AND poor physical health AND/OR poor mental health AND/OR poor social functioning

Exclusion Criteria

- Current major depression, current suicidality, current OCD.
- Current psychosis and no history of psychosis
- (history of) severe neurological disorders
- Contraindication to perform the operation
- Contraindication to participate in fMRI and/or SPECT assesment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome measurements include subjective craving and illicit drug use.<br /><br>In addition, urinalysis will be performed to validate self-reported drug use.<br /><br>Concerning the imaging experiments the outcome will be assessed by changes in<br /><br>brain activity with fMRI and changes in striatal dopamine D2 binding with<br /><br>SPECT. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes include social function and quality of life.</p><br>