Deep brain Stimulation for Addiction.

Recruiting

• Conditions: Heroine dependenceCocaine dependencedrug addiction

• Registration Number: NL-OMON26324
• Lead Sponsor: Academic Medical Center Amsterdam

Brief Summary

1. Luigjes J, van den Brink W, Feenstra M, van den Munckhof P, Schuurman PR, Schippers R, e.a. Deep brain stimulation in addiction: a review of potential brain targets. Mol. Psychiatry 2011 doi: http://www.ncbi.nlm.nih.gov/pubmed/21931318;<br> 2. Valencia-Alfaonso CE, Luigjes J, Smolders R, Cohen MX, Levar N, Mazaheri A, van den Munckhof P, Schuurman PR, van den Brink W, Denys D. Effective deep brain sitmulation in heroin addiction: a case report with complementary intracranial electroencephalogram. Biol Psychiatry 2012 71 e35-37

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 8

Inclusion Criteria

1. Minimal duration of 5 years of the DSM-IV diagnosis heroin and/or cocaine dependence;

2. Treatment refractory on other evidence based interventions;

Exclusion Criteria

1. Current suicidality;

2. Current psychosis and no history of psychosis;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Drug use: gr/day by interview and urine testing;<br /><br>2. Drug craving: DDQ, OCDUS;<br /><br>3. Neuropsychological functioning: CANTAB;<br /><br>4. Changes brain activation: fMRI.

Secondary Outcome Measures

Name	Time	Method
1. Changes in eating and sexual activity: interview;<br /><br>2. Depression: Hamilton depression scale;<br /><br>3. OCD symptoms: Y-BOCS;<br /><br>4. Smoking: FTND.