Deep Brain Stimulation in Patients with Chronic Treatment Refractory Anorexia Nervosa: a Pilot Study
- Conditions
- Anorexia nervosaself starvationeating disorder100030181001406710009720
- Registration Number
- NL-OMON47057
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 4
Inclusion criteria studypopulation:
• Primary diagnosis: Anorexia Nervosa (restricting or purging type; 307.1) according to the DSM-IV criteria based on a psychiatric interview
• Chronicity, defined by an illness duration > 10 years
• Disabling severity with substantial functional impairment according to the DSM-IV criterion C and a Global Assessment of Function (GAF) score of 45 or less for at least two years
• Treatment refractoriness, defined as lack of response to two or more typical modes of treatment , including one hospital admission or inpatient treatment in a specialized clinic, as described in the Multidisciplinaire Richtlijn Eetstoornissen (Trimbosinstituut 2008).
• BMI < 15 (level of severity acoording to the DSM 5: extreme)
• Age: 25-65 years old
• Written informed consent
• Dutch or English speaking and able to answer the study questions
• Able to fully understand the consequences of the procedure
• Capable to make his or her own choice without coercion ;Inclusion criteria healthy controlgroup EEG-substudy:
1. Female
2. 25-50 years
3. Matched intelligence level (NLV/DART)
4. Healthy BMI (18.5-25)
Exclusion criteria studypopulation:
• Unstable physical condition (severe electrolyte disturbances, cardiac failure, other physical contraindications for surgery/anesthesia). The use of anticoagulants must be able to be stopped before surgery
• Treatable underlying cause of anorexia/underweight
• Active neurological disease like Parkinson*s disease, dementia, epilepsy
• Schizophrenia/history of psychosis, bipolar disorder
• Alcohol or substance abuse (including benzodiazepines) during last 6 months
• Current Tic disorder
• Antisocial personality disorder
• Standard MRI scan exclusion criteria (pregnancy, pacemaker and metals contraindicated for MRI);Exclusion criteria healthy control group EEG-substudy:
1. (History of) eating disorders
2. (History of) psychiatric disorders
3. Relevant somatic/neurological disorders
4. Use of psychoactive drugs/substances
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method