Imaging Collagen Content in Human Coronary Atherosclerosis and Assessing its Role in Plaque Progression and Destabilization: A Clinical OCT-polarimetry Study
Not Applicable
- Conditions
- Patients with coronary artery disease
- Registration Number
- JPRN-UMIN000046910
- Lead Sponsor
- Osaka City University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 600
Inclusion Criteria
Not provided
Exclusion Criteria
1. patients diagnosed by physician as hemodynamically unstable at the time of enrollment 2. patients who cannot undergo coronary angiography or intracoronary imaging due to allergy to contrast media 3. patients with severe renal failure (eGFR less than 30ml/min/1.73mm2) who are not on maintenance dialysis 4. patients with a life expectancy of less than 1 year 5. pregnant women Patients who are judged unsuitable for participation in this study by the principal investigator or sub-investigator for other reasons.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The polarization characteristics (birefringence and degree of polarization resolution) of coronary artery lesions that develop ACS will be analyzed and compared with those of lesions in patients with CCS to identify determinants of ACS development (in patients who develop ACS due to in-stent restenosis or stent thrombosis, the polarization characteristics will be compared with those of in-stent neointima in patients with CCS).
- Secondary Outcome Measures
Name Time Method