Molecular imaging of coronary plaque vulnerability using 18F-fluorocholine PET-MRI in patients with coronary artery disease

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 35

Inclusion Criteria

Protocol optimization (stable AP patients included at MUMC+: additional PET-MRI);* Diagnosed with stable angina pectoris and scheduled for a PCI procedure at the MUMC
* Minimum age of 18 years
* Mentally competent
* Having provided informed written consent ;Patients included at Viecuri hospital: additional PET-MRI and OCT;* NSTEMI or STEMI patients who underwent urgent percutaneous coronary intervention (PCI) of the culprit vessel, who are diagnosed with multivessel coronary disease and are currently scheduled for a second PCI at the VieCuri hospital
* Currently stable and scheduled for another PCI at the VieCuri hospital to stent another coronary vessel
* Able to visit the MUMC by own transport / train for PET-MR imaging before the new PCI procedure
* Minimum age of 18 years
* Mentally competent
* Having provided informed written consent

Patients included at MUMC+: additional PET-MRI;* Recently diagnosed with NSTEMI and scheduled for a PCI at the MUMC
* GRACE risk score between 90 and 140
* Acute Coronary Syndrome (ACS) type 1
* Minimum age of 18 years
* Mentally competent
* Having provided informed written consent

Exclusion Criteria

* Conservatively managed patients who are not scheduled for percutaneous coronary intervention (PCI)
* Patients requiring PCI < 24 hours after admission
* Hemodynamic instability and cardiogenic shock (mean arterial pressure < 60 mmHg)
* Severe heart failure (Killip Class * III)
* Chest pain highly suggestive of non-cardiac origin (as judged by the cardiac
physician/cardiologist)
* Atrial fibrillation with ventricular rate *100 beats per minute (bpm)
* Tachycardia (* 100/bpm)
* Pregnancy
* Breast feeding women
* Contraindications to MRI

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* To investigate whether vulnerable plaques on OCT (fibrous cap * 70 m) show a<br /><br>locally increased uptake of 18F-choline on PET-MRI compared to stable plaques.<br /><br> To investigate whether the culprit plaque shows a locally increased uptake of<br /><br>18F-choline on PET-MRI compared to non-culprit plaques.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* To study whether there is a correlation between the uptake of 18F-choline in<br /><br>coronary plaques and the degree of stenosis as shown on the angiogram acquired<br /><br>during the PCI procedure<br /><br>* To study whether there is a correlation between the uptake of 18F-choline in<br /><br>coronary plaques and the presence of macrophages, micro-calcifications,<br /><br>lipid-rich necrotic core on OCT<br /><br>* To investigate whether there is an association between the uptake of<br /><br>18F-choline in the coronary arteries and that in the carotid arteries.</p><br>