Plaque at risk (ParisK): Molecular imaging of plaque vulnerability using 18F-choline PET-MRI in patients with carotid artery atherosclerosis

Phase 3

Recruiting

• Conditions: arteriosclerosis; atherosclerotic plaque; calcification in the vessel wall; 10003216

• Registration Number: NL-OMON47871
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 25

Inclusion Criteria

- Patients known with symptomatic carotid artery stenosis (who are planned in the clinical setting for a carotid endarterectomy or who are referred to conservative therapy);
- Age 18 years or older (no maximum age);
- Informed consent by signing informed consent form regarding this study.

Exclusion Criteria

- Dementia, pregnancy, nursing mothers;
- Serious neurological deficits at symptomatic side (hemi paralysis, complete aphasia);
- Severe heart failure NYHA III-I and severe pulmonary dysfunction;
- Contra-indications for MRI, such as ferromagnetic implants.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Positive correlation between 18F-choline uptake on PET and degree of<br /><br>intraplaque inflammation on histology.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-The correlation between 18F-choline uptake as assessed by PET-MRI, FDG PET-MRI<br /><br>parameters of plaque vulnerability;<br /><br>-The association between the degree of 18F-choline uptake on PET with the<br /><br>cardiovascular risk profile and history of patients.</p><br>