Contribution of High Resolution EEG Functional Connectivity Measures to Presurgical Evaluation of Patients With Intractable Epilepsy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- The quality of matching between i) the graphs produced by the evaluated connectivity method(s) applied to the HR-EEG and ii) the results of the visual analysis typically performed by an expert on the standard EEG recorded during intercritical phase.
研究概览
简要总结
Electroencephalography (EEG) with very high spatial resolution (HR-EEG, 256 electrodes) allow for better analysis of local and global activity of the cerebral cortex, as compared with conventional EEG. Since January 2012, the Neurology Department of CHU Rennes is the first clinical service in France equipped with such a system.
Applied to HR-EEG recordings, brain connectivity methods are likely to provide essential information (in the form of "connectivity graphs") on cortical networks, either dysfunctional or not, involved in the generation of interictal paroxysms (like spikes or spike-waves) and during seizures.
So far, many methods have been proposed (see for a review: Wendling et al., 2009; Wendling et al., 2010). However, since each method is highly sensitive to the type of model that is assumed for the underlying relationship between distinct brain regions (Ansari-Asl et al., 2006), none of them has yet demonstrated its effectiveness.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being more than 18 years old,
- •Having a chronic partial epilepsy resistant to medical treatments well administered and well followed in the course of pre-surgical assessment.
- •Inclusion Criteria Healthy Volunteers:
- •Being French native speaker,
- •Being more than 18 years old,
- •Being right-handed.
排除标准
- •All patients for whom a preoperative surgical exam is not suitable,
- •Any patient with psychiatric disease or intellectual disorder such that informed consent could not be obtained,
- •Any patient with no abnormal EEG during intercritical phases,
- •All patients presenting psychiatric, neuropsychological or developmental difficulties in addition to epilepsy,
- •Adult persons subject to legal protection (judicial protection, temporary guardianship/guardianship, administrative supervision), persons deprived of their liberty and pregnant or lactating women.
- •Exclusion Criteria Healthy Volunteers:
- •The presence of any psychiatric, neuropsychological, and developmental disorder,
- •Any uncorrected visual impairment,
- •Any trouble or delay in learning to read / speak or write French,
- •Being fully bilingual or multilingual
- •Medication, treatment and / or substances that may alter or modify brain functions,
- •Adult persons subject to legal protection (judicial protection, temporary guardianship/guardianship, administrative supervision), persons deprived of their liberty and pregnant or lactating women.
结局指标
主要结局
The quality of matching between i) the graphs produced by the evaluated connectivity method(s) applied to the HR-EEG and ii) the results of the visual analysis typically performed by an expert on the standard EEG recorded during intercritical phase.
时间窗: 2 years
Main objective :To determine which functional connectivity estimation method(s) show(s) best performance(s) for the identification of epileptogenic networks from the HR-EEG recording performed in epileptic patients.
次要结局
- The quality of matching between i) the connectivity graphs obtained from control subjects performing a well defined cognitive task to ii) data from the literature on networks activated and sustaining these cognitive processes.(2 years)