High-density EEG in Neurological Disorders

Not Applicable

• Conditions: Epilepsy; Healthy; Tumor
• Interventions: Diagnostic Test: High-density electroencephalogram (HD-EEG)

• Registration Number: NCT04266041
• Lead Sponsor: Dartmouth-Hitchcock Medical Center

Brief Summary

The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.

Detailed Description

This study will measure brain waves using high-density EEG. Participants will be asked wear a cap with electrodes attached to it. During the recording, participants may be asked to rest, sleep, or complete a task. The tasks involve viewing pictures, answering questions, speaking, or moving an arm or leg. Recordings generally last between 60-120 minutes.\*

Study Timeline

• Study Start: 2018-02-09
• Study First Submitted: 2020-02-10
• Study First Submitted QC: 2020-02-10
• Study First Posted: 2020-02-12
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-07
• Last Update Posted: 2025-02-11
• Primary Completion: 2028-02-09
• Study Completion: 2028-03-09

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Able to perform the tasks
• Able to give own consent

Exclusion Criteria

• Any neurologic or psychiatric diagnosis such as stroke, tumor, or psychosis judged to interfere with high-density EEG.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
High-density EEG localization in epilepsy	High-density electroencephalogram (HD-EEG)	High-density EEG will be used for brain localization in epilepsy patients
High-density EEG localization in tumor patients	High-density electroencephalogram (HD-EEG)	High-density EEG will be used for brain localization in tumor patients
High-density EEG localization in stroke patients	High-density electroencephalogram (HD-EEG)	High-density EEG will be used for brain localization in patients who have recently experienced a stroke
High-density EEG localization in healthy controls	High-density electroencephalogram (HD-EEG)	High-density EEG will be used for brain localization in healthy controls
High-density EEG localization in peripheral nerve patients	High-density electroencephalogram (HD-EEG)	High-density EEG will be used for brain localization in patients with peripheral nerve dysfunction

Primary Outcome Measures

Name	Time	Method
Localize brain functions in patients and healthy controls	At baseline for approximately 60 - 90 minutes	Localize brain functions using high-density EEG recordings

Secondary Outcome Measures

Name	Time	Method
Localize brain areas involved in sensation	At baseline for approximately 60 - 90 minutes	Localize brain areas involved in sensation using high-density EEG recordings
Localize brain areas involved in emotion	At baseline for approximately 60 - 90 minutes	Localize brain areas involved in emotion using high-density EEG recordings
Localize brain areas associated with lesions	At baseline for approximately 60 - 90 minutes	Localize brain areas associated with lesions using high-density EEG recordings
Localize brain areas involved in language	At baseline for approximately 60 - 90 minutes	Localize brain areas involved in language using high-density EEG recordings
Localize brain areas involved in movement	At baseline for approximately 60 - 90 minutes	Localize brain areas involved in movement using high-density EEG recordings
Localize brain areas involved in memory	At baseline for approximately 60 - 90 minutes	Localize brain areas involved in memory using high-density EEG recordings

Trial Locations

Locations (1)

Dartmouth-Hitchcock Medical Center; 🇺🇸 Lebanon, New Hampshire, United States