Rational Optimization of tACS for Targeting Thalamo-Cortical Oscillations (Experiment 2)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Salivary Cortisol
研究概览
简要总结
Transcranial Alternating Current Stimulation (tACS) is one method that has been demonstrated to enhance alpha oscillations in healthy participants by applying weak electrical currents to the scalp to modulate rhythmic brain activity patterns. This study will involve tACS-induced frontal alpha oscillations, EEG recordings, and other physiological and biological measures.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
This study will follow a double-blind experimental design, so neither the participant nor the experimenter will know what kind of stimulation the participant is receiving at what session. A separate unblinded monitor, who will not interact with the participants, will be responsible for creating the stimulation codes for each session.
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Ages 18-65
- •Capacity to understand all relevant risks and potential benefits of the study (informed consent)
- •Negative pregnancy test for female participants
排除标准
- •History of major neurological or psychiatric illness, including epilepsy
- •Medication use associated with neurological or psychiatric illnesses
- •Currently undergoing counseling or psychotherapy treatment for depression, anxiety, eating disorders, PTSD or other behavioral conditions
- •First degree relative (parent, sibling, child) with major neurological or psychiatric illness
- •Prior brain surgery
- •Major head injury
- •Any brain devices/implants (including cochlear implants and aneurysm clips)
- •Braids or other hair styling that prevents direct access to the scalp (if removal not possible)
- •Skin allergies or very sensitive skin
- •Pregnant or nursing females
- •Failure to pass a urinary drug test at the first session
- •Use of hormonal birth control or supplements in the past two weeks
- •Non English speakers
- •Cardiovascular disease
结局指标
主要结局
Salivary Cortisol
时间窗: Before and after 40 minutes of stimulation
Change before and after stimulation
Salivary Alpha Amylase
时间窗: Before and after 40-minute stimulation at each session.
Change after stimulation
次要结局
- Heart Rate Variability(Before and after 40-minute stimulation at each session.)
- Percent Change in Respiration(Before and after 40-minute stimulation at each session.)
- Electroencephalogram (EEG)(Before and after 40-minute stimulation at each session.)