Prophylactic effect of oral Tranexamic Acid on bleeding in knee replacement surgery

Phase 4

Recruiting

Conditions: Joint knee replacement hemorrhage.

Registration Number: IRCT20190220042773N1

Lead Sponsor: Islamic Azad University

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

The patient's full conditions for participation in the study and signature of the prepared form of the informed consent
A person with a history of specific disease, such as kidney disease, liver disease, history of ischemia, heart, hypertension, history of self-sacrifice and signs of disability in the diagnosis and treatment of disability.
Patients do not use aspirin or any other anticoagulants from the week before surgery: Plavix, heparin, enoxaparin, and warfarin.
Do not observe a specific diet (it's not just herbivorous or meat-eaters, or the use of certain substances that lower blood glucose levels)
Do not use special medication such as iron or other medications associated with bleeding.

Exclusion Criteria

Patient dissatisfaction to continue participation
Patients with abnormal clotting parameters (PT, PTT, BT, INR, platelet)
People with high systolic blood pressure (185 in surgery day)
During surgery and up to 6 hours after the operation, the osmotic arterial pressure is more than 20%.
Patients with complications such as nausea and vomiting, color blindness, headache and dizziness, thromboemboli, myocardial ischemia and nutritional ischemia before and after surgery.

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Volume of bleeding in knee replacement surgery. Timepoint: During surgery and 6 hours after surgery and 12 hours after knee replacement. Method of measurement: Level of hemoglobin and platelets, PT, PTT, BT before and after the operation, the amount of blood lost through surgical suction bottles, weighing the used gauzes during surgery and blood on the field of postoperative surgery patients.

Secondary Outcome Measures