A study to assess the effect Of the drug Tranexamic acid in reducing bloos loss during early excision of burn wound.
Phase 4
- Conditions
- Health Condition 1: null- Those Who Sustained Less Than 40% Burns And Hemodynamically Stable
- Registration Number
- CTRI/2017/09/009629
- Lead Sponsor
- Dept Of Plastic Surgery
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients presenting with thermal burns involving upto 30% TBSA with deep thermal component of atleast 5 % TBSA.
2.The thermal injury should be less than or equal to 6 days old
3.Age between 15-50 years
Exclusion Criteria
1.Inhalational injury
2.Chemical & electrical burns
3.Burn injury >6 days old
4.Associated major injuries (head,chest,abdominal trauma)
5.Patient with history of bleeding disorders and on anticoagulation treatment
6.Non consenting patients
7.H/o Deep Vein Thrombosis,Myocardial infarction,CerebroVascular accident
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To find the difference in average blood loss per cm2 area excised in patients who are given intravenous tranexamic acid during early tangential excision grafting of the burn wounds versus a control group <br/ ><br>To find the average amount of blood transfusion requirement per cm2 area excised and average fluid requirements during the intra operative period <br/ ><br>Timepoint: at the time of primary dressing,ie on post operative day 5 <br/ ><br>
- Secondary Outcome Measures
Name Time Method TO Find the average blood transfusion required per cm2 during tangential excision. <br/ ><br>Percentage of graft takeTimepoint: On post operative day 5