The Effects of Trans Venous Cardiac Pacing on Coronary Microvascular Function and Hemodynamics
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- Patients that exhibit coronary microvascular resistance and dysfunction as reflected by FFR
研究概览
简要总结
The study will examine role of transvenous pacing on coronary microcirculation.
详细描述
To study the role of transvenous pacing on the coronary microcirculation. This will be accomplished by gathering data from invasive Fractional Flow Reserve (FFR) and Coronary Flow Reserve (CFR) with and without ventricular pacing.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients 19 years of age or older with clinical evidence of coronary ischemia undergoing coronary angiogram, and who have a pacemaker.
排除标准
- •Acute ST segment myocardial infarction
- •Known sensitivity or contraindication to the agents planned for administration during coronary angiography
- •Pacemaker dependent patients
- •Pregnancy
- •Hypotension (a systolic blood pressure lower than 90mmHg) that would preclude the administration of adenosine
- •Severe renal dysfunction, defined as a estimated glomerular filtration (eGFR) less than 30ml/min, confirmed by recent testing
- •Study subject has any underlying disorder that, in the opinion of the investigator, precludes them from giving informed consent at the time of enrollment
研究组 & 干预措施
Right ventricular Pacemaker
Patients with right ventricular pacing and evidence of coronary ischemia who have evidence of coronary ischemia who are to undergo coronary angiogram.When an intermediate stenosis (40-80%) has been identified angiographically, this lesion will undergo further hemodynamic assessment, All data including resting flow, FFR, CFR, vital signs, arrhythmias and patient symptoms will be recorded twice: once when the pacemaker is programmed to pace, and once when the PPM is reprogrammed such that the pacemaker is no longer pacing.
干预措施: Coronary flow and pressure measurement in patients with ventricular pacing (Diagnostic Test)
Biventricular Pacemaker
Patients with Biventricular pacing and evidence of coronary ischemia who have evidence of coronary ischemia who are to undergo coronary angiogram.When an intermediate stenosis (40-80%) has been identified angiographically, this lesion will undergo further hemodynamic assessment, All data including resting flow, FFR, CFR, vital signs, arrhythmias and patient symptoms will be recorded twice: once when the pacemaker is programmed to pace, and once when the PPM is reprogrammed such that the pacemaker is no longer pacing.
干预措施: Coronary flow and pressure measurement in patients with ventricular pacing (Diagnostic Test)
结局指标
主要结局
Patients that exhibit coronary microvascular resistance and dysfunction as reflected by FFR
时间窗: Up to 12 months
Microvascular dysfunction with pacing
次要结局
- Patients that exhibit coronary microvascular resistance and dysfunction as reflected by CFR(Up to 12 months)