Immunogenicity and Safety of Inactivated Hepatitis A Vaccine in HIV-infected People
- Conditions
- HIV InfectionsHepatitis AImmunodeficiency
- Interventions
- Biological: 2 doses of HAVBiological: At least one dose of HAV
- Registration Number
- NCT06576024
- Lead Sponsor
- LiuZhou People's Hospital
- Brief Summary
Approximately 400 HIV-infected participants aged 1-40 years old will be recruited according to the inclusion and exclusion criteria. Among them, more than 180 participants will be recruited in the immunogenicity and safety study. Each of them will receive 2 doses of HAV vaccines with a 6-month interval. Blood samples will be drawn before and 1 month after each dose to detect the HAV anitibodies to evaluate the immunogenicity of the vaccines. Other people will be recruited in the safety study and receive at least one dose of HAV vaccine. All the participants will report the adverse events within one month after each dose.
- Detailed Description
Approximately 400 HIV-infected participants aged 1-40 years old will be recruited in terms of inclusion and exclusion criteria. All participants will receive one dose of hepatitis A vaccine and have their blood and urine samples collected before and after vaccination for laboratory-related indicator testing. At least 120 HAV-susceptible participants (with anti-HAV antibodies negative before vaccination) and 60 HAV-unsusceptible participants (with anti-HAV antibodies positive before vaccination) aged 18-40 years old, and an unlimited number of HIV-infected children aged 1-17 years old will be included into immunogenicity study, with rest participants included into safety study. Participants in immunogenicity study will receive the second dose of hepatitis A vaccination with a 6-month interval. Blood and urine samples will be collected 1 month,6months (before second vaccination), and 7 months (1month after second vaccination) after the first vaccination. Participants in safety study will receive second vaccination voluntarily. Adverse events in both immunogenicity and safety study will be collected within 30 days after each dose of vaccination using smartphone mini program or diary cards.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 400
- HIV-infected participants aged 1-40 years old
- The HIV viral loads of participants in the past 12 months were supposed to be less than 200 copies/ml
- Participants or his/her guardian can fully understand and voluntarily sign the informed consent 4. Participants who are willing to participate in the 7-month follow-up 5. Participants who can provide valid legal identification
- Participants who have infected with hepatitis A;
- Participants who have been vaccinated with inactivated or live-attenuated hepatitis A vaccine, or hepatitis A and B combined vaccine
- Participants who are allergic constitution or severe allergic to vaccines or components in the past (such as acute allergic reaction, angioedema, dyspnea, etc.)
- Pregnant women and lactating women
- People suffering from uncontrolled epilepsy and other serious neurological diseases (such as transverse myelitis, Guillain-Barré syndrome, demyelinating diseases, etc.)
- Participants with fever (axillary temperature ≥37.3℃) during vaccination, or acute exacerbation of chronic diseases, or participants with uncontrolled severe chronic diseases, or suffering from acute diseases
- Participants who have received other experimental drugs within 30 days before vaccination with the experimental vaccine
- Participants who have received live-attenuated vaccine withins 14 days before vaccination with the experimental vaccine
- Participants who have received subunit or inactivated vaccines within 7 days before vaccination with experimental vaccine
- According to the investigator's judgment, participants who has any other factors that make him or her unsuitable for vaccination
Exclusion Criteria of second vaccination:
Participants who meet one of the following events (1) to (4), should not receive the second vaccination, but can continue other study steps according to the investigator's judgment; if participants who meet one of the following events (5) or (6), can still receive the second vaccination according to the investigator's judgment.
Participants who meet one of the following events (7) to (10) can postponed the second vaccination within the time window specified in the protocal.
- Vaccines of the same type other than the experimental vaccine were used during the study;
- Any serious adverse reaction that is causally related to the experimental vaccination
- Severe allergic reaction or hypersensitivity reaction after vaccination (including urticaria/rash occurring within 30 minutes after vaccination)
- Pregnant after the first vaccination (those who had positive result for urine pregnancy test or those who are known to be pregnant)
- Acute or recently diagnosed chronic disease that occurred after the first vaccination
- Other reactions (including severe pain, severe swelling, severe limitation of activity, persistent high fever, severe headache, or other systemic or local reactions) are diagonosed by investigator
- Suffering from acute illness (acute illness refers to moderate or severe illness with or without fever);
- Axillary temperature ≥37.3℃ during vaccination;
- Have received subunit vaccine or inactivated vaccine within 7 days, and have received live attenuated vaccine within 14 days
- According to the investigator's judgment, participants who has any other factors that make him or her unsuitable for vaccination
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description HAV susceptible participants aged 18-40 years old 2 doses of HAV HAV susceptible participants aged 18-40 years old in the immunogenicity and safety study HAV unsusceptible participants aged 18-40 years old 2 doses of HAV HAV unsusceptible participants aged 18-40 years old in the immunogenicity and safety study Participants aged 1-17 years old 2 doses of HAV Participants aged 1-17 years old in the immunogenicity and safety study Other participants aged 18-40 years old At least one dose of HAV Other participants aged 18-40 years old in the safety study
- Primary Outcome Measures
Name Time Method Incidences of adverse reactions within 30 days after each dose of hepatitis A vaccination 0-30 days after each dose of hepatitis A vaccination safety evaluation
Seroconversion rate of anti-HAV antibodies 30 days after 2 doses of hepatitis A vaccination among HIV-infected participants with hepatitis A susceptibility 30 days after 2 doses of hepatitis A vaccination Immunogenicity evaluation
- Secondary Outcome Measures
Name Time Method GMIs of anti-HAV antibodies 30 days after 2 doses of hepatitis A vaccination among HIV-infected participants with hepatitis A susceptibility 30 days after 2 doses of hepatitis A vaccination Immunogenicity evaluation
GMIs of anti-HAV antibodies 30 days and 6 months after 1 dose of hepatitis A vaccination among HIV-infected participants without hepatitis A susceptibility 30 days and 6 months after 1 dose of hepatitis A vaccination Immunogenicity evaluation
Incidences of adverse events within 7 days and within 30 days after each dose of hepatitis A vaccination 0-7 days and 0-30 days after each dose of hepatitis A vaccination safety evaluation
Seroconversion rates of anti-HAV antibodies 30 days and 6 months after the first dose of hepatitis A vaccination among HIV-infected participants with hepatitis A susceptibility 30 days and 6 months after one dose of hepatitis A vaccination Immunogenicity evaluation
Incidences of adverse reactions within 7 days after each dose of hepatitis A 0-7 days after each dose of hepatitis A vaccination safety evaluation
Seropositive rates of anti-HAV antibodies 30 days after 2 doses of hepatitis A vaccination among HIV-infected participants with hepatitis A susceptibility 30 days after 2 doses of hepatitis A vaccination Immunogenicity evaluation
Seroconversion rates of anti-HAV antibodies 30 days after 1 does, 30 days and 6 months after 2 doses of hepatitis A vaccination among HIV-infected participants with anti-HAV antibodies seropositivity 30 days after 1 dose, 30 days and 6 months after 2 doses of hepatitis A vaccination Immunogenicity evaluation
GMC of anti-HAV antibodies 30 days after 1 does, 30 days and 6 months after 2 doses of hepatitis A vaccination among HIV-infected participants with anti-HAV antibodies seropositivity 30 days after 1 dose, 30 days and 6 months after 2 doses of hepatitis A vaccination Immunogenicity evaluation
GMCs of anti-HAV antibodies 30 days and 6 months after 1 dose of hepatitis A vaccination among HIV-infected participants without hepatitis A susceptibility 30 days and 6 months after 1 dose of hepatitis A vaccination Immunogenicity evaluation
The difference in virus loads of HIV before and after vaccination among HIV-infected people before and within 1 year after vaccination safety evaluation
GMCs of anti-HAV antibodies 30 days after 2 doses of hepatitis A vaccination among HIV-infected participants with hepatitis A susceptibility 30 days after 2 doses of hepatitis A vaccination Immunogenicity evaluation
Seropositive rates of anti-HAV antibodies 30 days and 6 months after 1 dose of hepatitis A vaccination among HIV-infected participants without hepatitis A susceptibility 30 days and 6 months after 1 dose of hepatitis A vaccination Immunogenicity evaluation
Seropositive rates of anti-HAV antibodies 30 days after 1 does, 30 days and 6 months after 2 doses of hepatitis A vaccination among HIV-infected participants with anti-HAV antibodies seropositivity 30 days after 1 dose, 30 days and 6 months after 2 doses of hepatitis A vaccination Immunogenicity evaluation
GMIs of anti-HAV antibodies 30 days after 1 does, 30 days and 6 months after 2 doses of hepatitis A vaccination among HIV-infected participants with anti-HAV antibodies seropositivity 30 days after 1 dose, 30 days and 6 months after 2 doses of hepatitis A vaccination Immunogenicity evaluation
Trial Locations
- Locations (1)
Liuzhou People's Hospital
🇨🇳Liuzhou, Guangxi, China