Prevalence and Prognostic Implications of Cardiac Injury in Patients With Influenza-like Illness
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Influenza, Human
- Sponsor
- Örebro University, Sweden
- Enrollment
- 466
- Locations
- 1
- Primary Endpoint
- Level of biochemical markers
- Status
- Active, not recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to myocardial infarction, unstable angina, heart failure and stroke.
Detailed Description
The relationship between influenza and cardiovascular events was described in an early study of influenza epidemics from 1915 to 1929 including the 1918-1920 pandemic. Retrospective studies have shown increased risk for acute myocardial infarction (AMI) during the first week following an infection with influenza. Biochemical markers of cardiac injury such as high sensitive cardiac troponins may be increased during infection with influenza. Increased levels of cardiac troponins are associated with adverse outcome in many different populations.
Investigators
Anna Nordenskjöld
Principal Investigator
Örebro University, Sweden
Eligibility Criteria
Inclusion Criteria
- •Adult patients (\>18 years) presenting with influenza-like illness.
- •Written informed consent.
Exclusion Criteria
- •Inability to provide informed consent.
- •Age \<18 years.
- •Symptoms indicating an acute coronary syndrome, acute heart failure, rapid atrial fibrillation or acute stroke.
Outcomes
Primary Outcomes
Level of biochemical markers
Time Frame: One year
Level of other biochemical markers in patients with influenza
Secondary Outcomes
- Prognostic implication(One year)