Cardiopulmonary Complication in Aneurysmal Subarachnoid Haemorrhage Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 198
- 试验地点
- 3
- 主要终点
- Incidence of cardiac failure and the impact of cardiac problems on morbidity
研究概览
简要总结
This is a prospective cohort study investigating cardiac function and cardiac biomarkers in patients with acute Aneurysmal Subarachnoid Haemorrhage (aSAH). The aims of the study are to document the incidence of myocardial dysfunction,to find the predictive factors of myocardial dysfunction, describe heart rate variability and to assess the impact of all cardiac problems on morbidity and mortality.
详细描述
Laboratory markers daily: Routine laboratory test (blood gases, haemoglobin, thrombocytes, leukocytes, INR, bilirubin, creatinine, c-reactive protein, CK, CK-MB, Tnt, BNP, sodium, potassium, magnesium) are taken at 8 a.m. Study laboratory tests (sensitive ischemia markers, remodelling marker MMP-9 and CgA as surrogate marker for increased sympathetic activity) are taken four times during study period at the same time as cardiac ECHOes and Holtering. Gene sample is taken once on day one.
Primary outcome measurement is to document the incidence of myocardial dysfunction and the predictive factors during the hospital stay and at three months.
Secondary outcome is to assess the impact of cardiac problems on morbidity and mortality during first three months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with nontraumatic subarachnoid haemorrhage
- •Age > 18 years
- •Aneurysmal bleeding
排除标准
- •No consent
- •Age < 18 years
- •Anticipated brain death < 24 hours
- •Otherwise moribund patient
结局指标
主要结局
Incidence of cardiac failure and the impact of cardiac problems on morbidity
时间窗: 6 months
The aims of the study are: 1. to document the incidence of myocardial dysfunction 2. to find the predictive factors of myocardial dysfunction as determined by the severity aneurysmal bleeding (Hunt and Hess-grading, Glasgow coma score, Fisher scale) and demographic factors 3. to find predictive factors for myocardial dysfunction as determined by laboratory findings, electrocardiography, and echocardiography 4. to describe heart rate variability 5. to assess the impact of all cardiac problems on morbidity
次要结局
未报告次要终点
研究者
Maarit Lang
MD
Kuopio University Hospital