NCT01801800已完成不适用
Speckle Tracking Assessment of Cardiac Function in Severe Aneurysmal Subarachnoid Haemorrhage and Impact on Neurologic Outcome (SPLASH)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Neurologic outcome
研究概览
简要总结
Cardiac dysfunction can occur in aneurysmal subarachnoid haemorrhage and might impact patient's neurologic outcome Condition Aneurysmal subarachnoid haemorrhage World Neurosurgeon Federation Score ≥ III
详细描述
Trans-thoracic echocardiography on day 1, day 3 and day 7 Speckle-Tracking of echocardiographic loops by a cardiologist blinded to the patient's management and outcome
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 85 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aneurysmal subarachnoid haemorrhage
- •World Neurosurgeon Federation Score ≥ III
- •Written information to next-of-kin and patients when possible
排除标准
- •History of myocardial infarction, chronic heart failure with NYHA ≥ 2, major heart surgery
- •Lack of acoustic window to perform trans-thoracic echocardiography
结局指标
主要结局
Neurologic outcome
时间窗: 3 months
modified Rankin Scale (mRS). Poor neurological outcome was considered as death or severe disability (mRS 5-6).
次要结局
- Correlation between cardiac strain on day 1 and Left Ventricular Ejection fraction(Day 1)
- Correlation between cardiac enzymes (NT-proBNP, troponin T US) and cardiac strain(Day 1)
- Correlation between EKG findings and cardiac strain(Day 1)
- Time to amines discontinuation(During Intensive Care Unit stay, expected average 17 days)
- Duration of mechanical ventilation(Duration of mechanical ventilation, expected average 15 days)
- Length of ICU stay(Duration of ICU stay, expected average 17 days)
- Correlation between Cardiac function and Mechanical Ventilation(Day1, day3, day7 and extubation time expected average 15 days)
- Correlation between Cardiac function and ICU length of stay(Day1, day3, day 7 and end of stay in ICU expected average 17 days)
研究者
研究点 (1)
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